Clinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical Microbiomics
A growing body of evidence shows that dysbiotic gut microbiota may correlate with a wide range of disorders; hence, the clinical use of microbiota maps and fecal microbiota transplantation (FMT) can be exploited in the clinic of some infectious diseases. Through direct or indirect ecological and fun...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/12/1550 |
| _version_ | 1797501709371572224 |
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| author | Stefania Pane Maria Vittoria Ristori Simone Gardini Alessandra Russo Federica Del Chierico Lorenza Putignani |
| author_facet | Stefania Pane Maria Vittoria Ristori Simone Gardini Alessandra Russo Federica Del Chierico Lorenza Putignani |
| author_sort | Stefania Pane |
| collection | DOAJ |
| description | A growing body of evidence shows that dysbiotic gut microbiota may correlate with a wide range of disorders; hence, the clinical use of microbiota maps and fecal microbiota transplantation (FMT) can be exploited in the clinic of some infectious diseases. Through direct or indirect ecological and functional competition, FMT may stimulate decolonization of pathogens or opportunistic pathogens, modulating immune response and colonic inflammation, and restoring intestinal homeostasis, which reduces host damage. Herein, we discuss how diagnostic parasitology may contribute to designing clinical metagenomic pipelines and FMT programs, especially in pediatric subjects. The consequences of more specialized diagnostics in the context of gut microbiota communities may improve the clinical parasitology and extend its applications to the prevention and treatment of several communicable and even noncommunicable disorders. |
| first_indexed | 2024-03-10T03:22:28Z |
| format | Article |
| id | doaj.art-6e203675406643d1938827b3c8c99601 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T03:22:28Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-6e203675406643d1938827b3c8c996012023-11-23T10:00:30ZengMDPI AGPathogens2076-08172021-11-011012155010.3390/pathogens10121550Clinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical MicrobiomicsStefania Pane0Maria Vittoria Ristori1Simone Gardini2Alessandra Russo3Federica Del Chierico4Lorenza Putignani5Microbiology and Diagnostic Immunology Unit, Unit of Microbiomics, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, ItalyMicrobiology and Diagnostic Immunology Unit, Unit of Microbiomics, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, ItalyGenomeUp, Via Nemorense 91, 00199 Rome, ItalyMicrobiology and Diagnostic Immunology Unit, Unit of Microbiomics, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, ItalyMultimodal Laboratory Medicine Research Area, Unit of Human Microbiome, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, ItalyMicrobiology and Diagnostic Immunology Unit, Unit of Microbiomics, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, ItalyA growing body of evidence shows that dysbiotic gut microbiota may correlate with a wide range of disorders; hence, the clinical use of microbiota maps and fecal microbiota transplantation (FMT) can be exploited in the clinic of some infectious diseases. Through direct or indirect ecological and functional competition, FMT may stimulate decolonization of pathogens or opportunistic pathogens, modulating immune response and colonic inflammation, and restoring intestinal homeostasis, which reduces host damage. Herein, we discuss how diagnostic parasitology may contribute to designing clinical metagenomic pipelines and FMT programs, especially in pediatric subjects. The consequences of more specialized diagnostics in the context of gut microbiota communities may improve the clinical parasitology and extend its applications to the prevention and treatment of several communicable and even noncommunicable disorders.https://www.mdpi.com/2076-0817/10/12/1550parasitesmicrobiotaFaecal Microbiota Transplantation (FMT) |
| spellingShingle | Stefania Pane Maria Vittoria Ristori Simone Gardini Alessandra Russo Federica Del Chierico Lorenza Putignani Clinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical Microbiomics Pathogens parasites microbiota Faecal Microbiota Transplantation (FMT) |
| title | Clinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical Microbiomics |
| title_full | Clinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical Microbiomics |
| title_fullStr | Clinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical Microbiomics |
| title_full_unstemmed | Clinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical Microbiomics |
| title_short | Clinical Parasitology and Parasitome Maps as Old and New Tools to Improve Clinical Microbiomics |
| title_sort | clinical parasitology and parasitome maps as old and new tools to improve clinical microbiomics |
| topic | parasites microbiota Faecal Microbiota Transplantation (FMT) |
| url | https://www.mdpi.com/2076-0817/10/12/1550 |
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