The KEAP1-NRF2 System in Healthy Aging and Longevity
Aging is inevitable, but the inherently and genetically programmed aging process is markedly influenced by environmental factors. All organisms are constantly exposed to various stresses, either exogenous or endogenous, throughout their lives, and the quality and quantity of the stresses generate di...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/12/1929 |
| _version_ | 1797506871670603776 |
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| author | Daisuke Matsumaru Hozumi Motohashi |
| author_facet | Daisuke Matsumaru Hozumi Motohashi |
| author_sort | Daisuke Matsumaru |
| collection | DOAJ |
| description | Aging is inevitable, but the inherently and genetically programmed aging process is markedly influenced by environmental factors. All organisms are constantly exposed to various stresses, either exogenous or endogenous, throughout their lives, and the quality and quantity of the stresses generate diverse impacts on the organismal aging process. In the current oxygenic atmosphere on earth, oxidative stress caused by reactive oxygen species is one of the most common and critical environmental factors for life. The Kelch-like ECH-associated protein 1-NFE2-related factor 2 (KEAP1-NRF2) system is a critical defense mechanism of cells and organisms in response to redox perturbations. In the presence of oxidative and electrophilic insults, the thiol moieties of cysteine in KEAP1 are modified, and consequently NRF2 activates its target genes for detoxification and cytoprotection. A number of studies have clarified the contributions of the KEAP1-NRF2 system to the prevention and attenuation of physiological aging and aging-related diseases. Accumulating knowledge to control stress-induced damage may provide a clue for extending healthspan and treating aging-related diseases. In this review, we focus on the relationships between oxidative stress and aging-related alterations in the sensory, glandular, muscular, and central nervous systems and the roles of the KEAP1-NRF2 system in aging processes. |
| first_indexed | 2024-03-10T04:38:35Z |
| format | Article |
| id | doaj.art-6e2083b5450e48b8a7a889c08df79958 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T04:38:35Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-6e2083b5450e48b8a7a889c08df799582023-11-23T03:33:04ZengMDPI AGAntioxidants2076-39212021-11-011012192910.3390/antiox10121929The KEAP1-NRF2 System in Healthy Aging and LongevityDaisuke Matsumaru0Hozumi Motohashi1Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, JapanDepartment of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, JapanAging is inevitable, but the inherently and genetically programmed aging process is markedly influenced by environmental factors. All organisms are constantly exposed to various stresses, either exogenous or endogenous, throughout their lives, and the quality and quantity of the stresses generate diverse impacts on the organismal aging process. In the current oxygenic atmosphere on earth, oxidative stress caused by reactive oxygen species is one of the most common and critical environmental factors for life. The Kelch-like ECH-associated protein 1-NFE2-related factor 2 (KEAP1-NRF2) system is a critical defense mechanism of cells and organisms in response to redox perturbations. In the presence of oxidative and electrophilic insults, the thiol moieties of cysteine in KEAP1 are modified, and consequently NRF2 activates its target genes for detoxification and cytoprotection. A number of studies have clarified the contributions of the KEAP1-NRF2 system to the prevention and attenuation of physiological aging and aging-related diseases. Accumulating knowledge to control stress-induced damage may provide a clue for extending healthspan and treating aging-related diseases. In this review, we focus on the relationships between oxidative stress and aging-related alterations in the sensory, glandular, muscular, and central nervous systems and the roles of the KEAP1-NRF2 system in aging processes.https://www.mdpi.com/2076-3921/10/12/1929KEAP1-NRF2 systemoxidative stressaginglongevitycell senescencetissue aging |
| spellingShingle | Daisuke Matsumaru Hozumi Motohashi The KEAP1-NRF2 System in Healthy Aging and Longevity Antioxidants KEAP1-NRF2 system oxidative stress aging longevity cell senescence tissue aging |
| title | The KEAP1-NRF2 System in Healthy Aging and Longevity |
| title_full | The KEAP1-NRF2 System in Healthy Aging and Longevity |
| title_fullStr | The KEAP1-NRF2 System in Healthy Aging and Longevity |
| title_full_unstemmed | The KEAP1-NRF2 System in Healthy Aging and Longevity |
| title_short | The KEAP1-NRF2 System in Healthy Aging and Longevity |
| title_sort | keap1 nrf2 system in healthy aging and longevity |
| topic | KEAP1-NRF2 system oxidative stress aging longevity cell senescence tissue aging |
| url | https://www.mdpi.com/2076-3921/10/12/1929 |
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