Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis
Purpose: To evaluate optical coherence tomography angiography findings in patients with multiple sclerosis (MS). Methods: This prospective noninterventional study was conducted on 30 eyes of relapsing-remitting MS patients. Group (1) included 10 eyes with a history of optic neuritis (ON), group (2)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=6;spage=1457;epage=1463;aulast=Khader |
| _version_ | 1818905644187516928 |
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| author | Sarah A Khader Amin E Nawar Azza A Ghali Ahmed M Ghoneim |
| author_facet | Sarah A Khader Amin E Nawar Azza A Ghali Ahmed M Ghoneim |
| author_sort | Sarah A Khader |
| collection | DOAJ |
| description | Purpose: To evaluate optical coherence tomography angiography findings in patients with multiple sclerosis (MS). Methods: This prospective noninterventional study was conducted on 30 eyes of relapsing-remitting MS patients. Group (1) included 10 eyes with a history of optic neuritis (ON), group (2) included 10 eyes without any history of optic neuritis (MS-ON), and group (3) included 10 eyes of normal age/sex/refraction matched participants. Optical coherence tomography (OCT) and OCT-A (ZEISS Cirrus™ HD-OCT Model 4000 (Carl Zeiss-Meditec, Dublin, CA) of the optic disc were done for all patients. Results: The best-corrected visual acuity was diminished in MS cases, especially in patients with ON with P value <0.001. The retinal nerve fiber layer (RNFL) thickness showed a significant decrease in the average thickness and in all quadrants, notably the temporal quadrant in group 1 (P < 0.001). Ganglion cell layer thickness was diminished in average thickness and in all quadrants in both groups of MS, but only the first group showed statistical significance with P value <0.001). In respect to optic disc perfusion, Average, superficial, and deep vascular density index (AVDI, VDI 1, VDI 2) were statistically significantly lower in groups 1, 2 with (P-value < 0.001). Conclusion: Decreased vascular perfusion of the optic nerve in MS patients, especially in those with ON is strongly correlated with the damage of RNFL and ganglion cell layer detected by OCT. |
| first_indexed | 2024-12-19T21:26:36Z |
| format | Article |
| id | doaj.art-6e212ebb063f4604be847c9ada7b106f |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-19T21:26:36Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-6e212ebb063f4604be847c9ada7b106f2022-12-21T20:05:07ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892021-01-016961457146310.4103/ijo.IJO_2964_20Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosisSarah A KhaderAmin E NawarAzza A GhaliAhmed M GhoneimPurpose: To evaluate optical coherence tomography angiography findings in patients with multiple sclerosis (MS). Methods: This prospective noninterventional study was conducted on 30 eyes of relapsing-remitting MS patients. Group (1) included 10 eyes with a history of optic neuritis (ON), group (2) included 10 eyes without any history of optic neuritis (MS-ON), and group (3) included 10 eyes of normal age/sex/refraction matched participants. Optical coherence tomography (OCT) and OCT-A (ZEISS Cirrus™ HD-OCT Model 4000 (Carl Zeiss-Meditec, Dublin, CA) of the optic disc were done for all patients. Results: The best-corrected visual acuity was diminished in MS cases, especially in patients with ON with P value <0.001. The retinal nerve fiber layer (RNFL) thickness showed a significant decrease in the average thickness and in all quadrants, notably the temporal quadrant in group 1 (P < 0.001). Ganglion cell layer thickness was diminished in average thickness and in all quadrants in both groups of MS, but only the first group showed statistical significance with P value <0.001). In respect to optic disc perfusion, Average, superficial, and deep vascular density index (AVDI, VDI 1, VDI 2) were statistically significantly lower in groups 1, 2 with (P-value < 0.001). Conclusion: Decreased vascular perfusion of the optic nerve in MS patients, especially in those with ON is strongly correlated with the damage of RNFL and ganglion cell layer detected by OCT.http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=6;spage=1457;epage=1463;aulast=Khaderganglion cell layermultiple sclerosisoptic neuritisoptical coherence tomographyoptical coherence tomography angiographyretinal nerve fiber layervascular density index |
| spellingShingle | Sarah A Khader Amin E Nawar Azza A Ghali Ahmed M Ghoneim Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis Indian Journal of Ophthalmology ganglion cell layer multiple sclerosis optic neuritis optical coherence tomography optical coherence tomography angiography retinal nerve fiber layer vascular density index |
| title | Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis |
| title_full | Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis |
| title_fullStr | Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis |
| title_full_unstemmed | Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis |
| title_short | Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis |
| title_sort | evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis |
| topic | ganglion cell layer multiple sclerosis optic neuritis optical coherence tomography optical coherence tomography angiography retinal nerve fiber layer vascular density index |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=6;spage=1457;epage=1463;aulast=Khader |
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