Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents [version 4; peer review: 2 approved]
Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metaboli...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wellcome
2022-08-01
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| Series: | Wellcome Open Research |
| Subjects: | |
| Online Access: | https://wellcomeopenresearch.org/articles/6-109/v4 |
| _version_ | 1817980886656745472 |
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| author | Eilidh MacNicol Diana Cash Eugene Kim Camilla Simmons Fernando Zelaya David J Lythgoe Federico Turkheimer Tobias C Wood |
| author_facet | Eilidh MacNicol Diana Cash Eugene Kim Camilla Simmons Fernando Zelaya David J Lythgoe Federico Turkheimer Tobias C Wood |
| author_sort | Eilidh MacNicol |
| collection | DOAJ |
| description | Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography. |
| first_indexed | 2024-04-13T22:58:40Z |
| format | Article |
| id | doaj.art-6e222b304ca14741a13934e0191a05ee |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-04-13T22:58:40Z |
| publishDate | 2022-08-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-6e222b304ca14741a13934e0191a05ee2022-12-22T02:25:55ZengWellcomeWellcome Open Research2398-502X2022-08-01620159Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents [version 4; peer review: 2 approved]Eilidh MacNicol0https://orcid.org/0000-0003-3715-7012Diana Cash1Eugene Kim2https://orcid.org/0000-0003-0066-7051Camilla Simmons3https://orcid.org/0000-0002-8561-4241Fernando Zelaya4David J Lythgoe5Federico Turkheimer6https://orcid.org/0000-0002-3766-3815Tobias C Wood7https://orcid.org/0000-0001-7640-5520Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UKMalfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.https://wellcomeopenresearch.org/articles/6-109/v4MRI CMRO2 CBF OEF Glucose Metabolismeng |
| spellingShingle | Eilidh MacNicol Diana Cash Eugene Kim Camilla Simmons Fernando Zelaya David J Lythgoe Federico Turkheimer Tobias C Wood Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents [version 4; peer review: 2 approved] Wellcome Open Research MRI CMRO2 CBF OEF Glucose Metabolism eng |
| title | Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents [version 4; peer review: 2 approved] |
| title_full | Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents [version 4; peer review: 2 approved] |
| title_fullStr | Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents [version 4; peer review: 2 approved] |
| title_full_unstemmed | Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents [version 4; peer review: 2 approved] |
| title_short | Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents [version 4; peer review: 2 approved] |
| title_sort | non invasive measurement of the cerebral metabolic rate of oxygen using mri in rodents version 4 peer review 2 approved |
| topic | MRI CMRO2 CBF OEF Glucose Metabolism eng |
| url | https://wellcomeopenresearch.org/articles/6-109/v4 |
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