Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus
Angiogenesis is the biological process by which new blood vessels are formed from pre-existing vessels. It is considered one of the classic hallmarks of cancer, as pathological angiogenesis provides oxygen and essential nutrients to growing tumors. Two of the seven known human oncoviruses, Epstein–B...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.01544/full |
| _version_ | 1818968001859289088 |
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| author | Ricardo Rivera-Soto Ricardo Rivera-Soto Blossom Damania Blossom Damania Blossom Damania |
| author_facet | Ricardo Rivera-Soto Ricardo Rivera-Soto Blossom Damania Blossom Damania Blossom Damania |
| author_sort | Ricardo Rivera-Soto |
| collection | DOAJ |
| description | Angiogenesis is the biological process by which new blood vessels are formed from pre-existing vessels. It is considered one of the classic hallmarks of cancer, as pathological angiogenesis provides oxygen and essential nutrients to growing tumors. Two of the seven known human oncoviruses, Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), belong to the Gammaherpesvirinae subfamily. Both viruses are associated with several malignancies including lymphomas, nasopharyngeal carcinomas, and Kaposi’s sarcoma. The viral genomes code for a plethora of viral factors, including proteins and non-coding RNAs, some of which have been shown to deregulate angiogenic pathways and promote tumor growth. In this review, we discuss the ability of both viruses to modulate the pro-angiogenic process. |
| first_indexed | 2024-12-20T13:57:45Z |
| format | Article |
| id | doaj.art-6e249355af2a4f9ba28e8cc8a0aca5f9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T13:57:45Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-6e249355af2a4f9ba28e8cc8a0aca5f92022-12-21T19:38:24ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-07-011010.3389/fmicb.2019.01544469832Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated HerpesvirusRicardo Rivera-Soto0Ricardo Rivera-Soto1Blossom Damania2Blossom Damania3Blossom Damania4Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesLineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesAngiogenesis is the biological process by which new blood vessels are formed from pre-existing vessels. It is considered one of the classic hallmarks of cancer, as pathological angiogenesis provides oxygen and essential nutrients to growing tumors. Two of the seven known human oncoviruses, Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), belong to the Gammaherpesvirinae subfamily. Both viruses are associated with several malignancies including lymphomas, nasopharyngeal carcinomas, and Kaposi’s sarcoma. The viral genomes code for a plethora of viral factors, including proteins and non-coding RNAs, some of which have been shown to deregulate angiogenic pathways and promote tumor growth. In this review, we discuss the ability of both viruses to modulate the pro-angiogenic process.https://www.frontiersin.org/article/10.3389/fmicb.2019.01544/fullangiogenesisEpstein–Barr virusgammaherpesvirusesKaposi’s sarcoma-associated herpesvirusoncovirusesvascular endothelial growth factor |
| spellingShingle | Ricardo Rivera-Soto Ricardo Rivera-Soto Blossom Damania Blossom Damania Blossom Damania Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus Frontiers in Microbiology angiogenesis Epstein–Barr virus gammaherpesviruses Kaposi’s sarcoma-associated herpesvirus oncoviruses vascular endothelial growth factor |
| title | Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus |
| title_full | Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus |
| title_fullStr | Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus |
| title_full_unstemmed | Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus |
| title_short | Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus |
| title_sort | modulation of angiogenic processes by the human gammaherpesviruses epstein barr virus and kaposi s sarcoma associated herpesvirus |
| topic | angiogenesis Epstein–Barr virus gammaherpesviruses Kaposi’s sarcoma-associated herpesvirus oncoviruses vascular endothelial growth factor |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.01544/full |
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