Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA
Introduction Lower extremity venous insufficiency is a significant health problem with economic and sociological consequences, lowering the quality of life, and sometimes leading to serious complications. The aim of this study is to evaluate the cytomegalovirus (CMV) effect on chronic inflammation i...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2019-05-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Evaluation-of-chronic-inflammation-in-the-aetiology-of-venous-insufficiency-by-investigating,103855,0,2.html |
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| author | Metin O. Beyaz Emre Bozkurt Mehmet A. Onalan Didem M. Oztas Mert Meric Mustafa Ozer Ulukan Ugur Coskun Murat Ugurlucan |
| author_facet | Metin O. Beyaz Emre Bozkurt Mehmet A. Onalan Didem M. Oztas Mert Meric Mustafa Ozer Ulukan Ugur Coskun Murat Ugurlucan |
| author_sort | Metin O. Beyaz |
| collection | DOAJ |
| description | Introduction
Lower extremity venous insufficiency is a significant health problem with economic and sociological consequences, lowering the quality of life, and sometimes leading to serious complications. The aim of this study is to evaluate the cytomegalovirus (CMV) effect on chronic inflammation in the aetiology of chronic venous insufficiency.
Material and methods
Between November 2017 and August 2018, 468 patients who underwent radio-frequency ablation therapy and phlebectomy were included in the study. PCR analyses for CMV DNA were performed on the venous tissue samples. Patients with post-thrombotic syndrome were excluded from the study. After ethical approval, the relationship between the presence of CMV DNA, gender, body mass index, and bilaterality of chronic venous insufficiency were investigated.
Results
When the relationship between CMV DNA and gender or body mass index was examined, a significant relationship was not detected. But when the patients with bilateral chronic venous insufficiency and patients with unilateral chronic venous insufficiency were compared regarding CMV DNA positivity, the patients with bilateral chronic venous insufficiency had significantly higher CMV DNA positivity (p = 0.002). Also, the incidence of venous ulcers in the CMV DNA exposed group was significantly higher.
Conclusions
In the literature there are many studies showing that CMV triggers atherosclerosis, but there is no study in which CMV directly produces chronic venous insufficiency. The high rates of positivity suggest that CMV, which is the basis of chronic inflammation, may be a significant factor in the aetiology of chronic venous insufficiency. |
| first_indexed | 2024-04-12T02:51:54Z |
| format | Article |
| id | doaj.art-6e25ac7dba1c495786b9b828745d8c8a |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-04-12T02:51:54Z |
| publishDate | 2019-05-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-6e25ac7dba1c495786b9b828745d8c8a2022-12-22T03:50:58ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512019-05-0118112913210.5114/aoms.2019.85232103855Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNAMetin O. Beyaz0Emre Bozkurt1Mehmet A. Onalan2Didem M. Oztas3Mert Meric4Mustafa Ozer Ulukan5Ugur Coskun6Murat Ugurlucan7Cardiovascular Surgery Clinic, Umraniye Education and Research Hospital, Istanbul, TurkeyGeneral Surgery Clinic, Gumushane Kelkit Hospital, Gumushane, TurkeyDepartment of Cardiovascular Surgery, Medical Faculty, Acibadem University, Istanbul, TurkeyCardiovascular Surgery Clinic, Bagcilar Education and Research Hospital, Istanbul, TurkeyDepartment of Cardiovascular Surgery, Medical Faculty, Istanbul University, Istanbul, TurkeyDepartment of Cardiovascular Surgery, Medical Faculty, Istanbul Medipol University, Istanbul, TurkeyCardiology Department, School of Medicine Karakum, Kyrenia University, Kyrenia, CyprusDepartment of Cardiovascular Surgery, Medical Faculty, Istanbul Medipol University, Istanbul, TurkeyIntroduction Lower extremity venous insufficiency is a significant health problem with economic and sociological consequences, lowering the quality of life, and sometimes leading to serious complications. The aim of this study is to evaluate the cytomegalovirus (CMV) effect on chronic inflammation in the aetiology of chronic venous insufficiency. Material and methods Between November 2017 and August 2018, 468 patients who underwent radio-frequency ablation therapy and phlebectomy were included in the study. PCR analyses for CMV DNA were performed on the venous tissue samples. Patients with post-thrombotic syndrome were excluded from the study. After ethical approval, the relationship between the presence of CMV DNA, gender, body mass index, and bilaterality of chronic venous insufficiency were investigated. Results When the relationship between CMV DNA and gender or body mass index was examined, a significant relationship was not detected. But when the patients with bilateral chronic venous insufficiency and patients with unilateral chronic venous insufficiency were compared regarding CMV DNA positivity, the patients with bilateral chronic venous insufficiency had significantly higher CMV DNA positivity (p = 0.002). Also, the incidence of venous ulcers in the CMV DNA exposed group was significantly higher. Conclusions In the literature there are many studies showing that CMV triggers atherosclerosis, but there is no study in which CMV directly produces chronic venous insufficiency. The high rates of positivity suggest that CMV, which is the basis of chronic inflammation, may be a significant factor in the aetiology of chronic venous insufficiency.https://www.archivesofmedicalscience.com/Evaluation-of-chronic-inflammation-in-the-aetiology-of-venous-insufficiency-by-investigating,103855,0,2.htmlcytomegalovirusvenous insufficiencychronic inflammation |
| spellingShingle | Metin O. Beyaz Emre Bozkurt Mehmet A. Onalan Didem M. Oztas Mert Meric Mustafa Ozer Ulukan Ugur Coskun Murat Ugurlucan Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA Archives of Medical Science cytomegalovirus venous insufficiency chronic inflammation |
| title | Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA |
| title_full | Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA |
| title_fullStr | Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA |
| title_full_unstemmed | Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA |
| title_short | Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA |
| title_sort | evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus dna |
| topic | cytomegalovirus venous insufficiency chronic inflammation |
| url | https://www.archivesofmedicalscience.com/Evaluation-of-chronic-inflammation-in-the-aetiology-of-venous-insufficiency-by-investigating,103855,0,2.html |
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