Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep
IntroductionCurrently, the anti-oxidation of active ingredients in mulberry leaves (MLs) and their forage utilization is receiving increasing attention. Here, we propose that MLs supplementation improves oxidative resistance and immunity.MethodsWe conducted a trial including three groups of growing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1088850/full |
| _version_ | 1828001445705678848 |
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| author | Xiaopeng Cui Yuxin Yang Minjuan Zhang Shuang Liu Hexin Wang Feng Jiao Lijun Bao Ziwei Lin Xinlan Wei Wei Qian Xiang Shi Chao Su Yonghua Qian |
| author_facet | Xiaopeng Cui Yuxin Yang Minjuan Zhang Shuang Liu Hexin Wang Feng Jiao Lijun Bao Ziwei Lin Xinlan Wei Wei Qian Xiang Shi Chao Su Yonghua Qian |
| author_sort | Xiaopeng Cui |
| collection | DOAJ |
| description | IntroductionCurrently, the anti-oxidation of active ingredients in mulberry leaves (MLs) and their forage utilization is receiving increasing attention. Here, we propose that MLs supplementation improves oxidative resistance and immunity.MethodsWe conducted a trial including three groups of growing mutton sheep, each receiving fermented mulberry leaves (FMLs) feeding, dried mulberry leaves (DMLs) feeding or normal control feeding without MLs.ResultsTranscriptomic and metabolomic analyses revealed that promoting anti-oxidation and enhancing disease resistance of MLs is attributed to improved tryptophan metabolic pathways and reduced peroxidation of polyunsaturated fatty acids (PUFAs). Furthermore, immunity was markedly increased after FMLs treatment by regulating glycolysis and mannose-6-phosphate pathways. Additionally, there was better average daily gain in the MLs treatment groups.ConclusionThese findings provide new insights for understanding the beneficial effects of MLs in animal husbandry and provide a theoretical support for extensive application of MLs in improving nutrition and health care values. |
| first_indexed | 2024-04-10T06:28:30Z |
| format | Article |
| id | doaj.art-6e27c50b3dcb4ba08acbdec2c9f47c04 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T06:28:30Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6e27c50b3dcb4ba08acbdec2c9f47c042023-03-01T13:13:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011310.3389/fimmu.2022.10888501088850Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheepXiaopeng CuiYuxin YangMinjuan ZhangShuang LiuHexin WangFeng JiaoLijun BaoZiwei LinXinlan WeiWei QianXiang ShiChao SuYonghua QianIntroductionCurrently, the anti-oxidation of active ingredients in mulberry leaves (MLs) and their forage utilization is receiving increasing attention. Here, we propose that MLs supplementation improves oxidative resistance and immunity.MethodsWe conducted a trial including three groups of growing mutton sheep, each receiving fermented mulberry leaves (FMLs) feeding, dried mulberry leaves (DMLs) feeding or normal control feeding without MLs.ResultsTranscriptomic and metabolomic analyses revealed that promoting anti-oxidation and enhancing disease resistance of MLs is attributed to improved tryptophan metabolic pathways and reduced peroxidation of polyunsaturated fatty acids (PUFAs). Furthermore, immunity was markedly increased after FMLs treatment by regulating glycolysis and mannose-6-phosphate pathways. Additionally, there was better average daily gain in the MLs treatment groups.ConclusionThese findings provide new insights for understanding the beneficial effects of MLs in animal husbandry and provide a theoretical support for extensive application of MLs in improving nutrition and health care values.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1088850/fullmulberry leavesanti-oxidationperoxidation of polyunsaturated fatty acidstryptophan metabolismimmunityglycolysis |
| spellingShingle | Xiaopeng Cui Yuxin Yang Minjuan Zhang Shuang Liu Hexin Wang Feng Jiao Lijun Bao Ziwei Lin Xinlan Wei Wei Qian Xiang Shi Chao Su Yonghua Qian Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep Frontiers in Immunology mulberry leaves anti-oxidation peroxidation of polyunsaturated fatty acids tryptophan metabolism immunity glycolysis |
| title | Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep |
| title_full | Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep |
| title_fullStr | Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep |
| title_full_unstemmed | Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep |
| title_short | Transcriptomics and metabolomics analysis reveal the anti-oxidation and immune boosting effects of mulberry leaves in growing mutton sheep |
| title_sort | transcriptomics and metabolomics analysis reveal the anti oxidation and immune boosting effects of mulberry leaves in growing mutton sheep |
| topic | mulberry leaves anti-oxidation peroxidation of polyunsaturated fatty acids tryptophan metabolism immunity glycolysis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1088850/full |
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