Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy
Diabetic nephropathy (DN) and diabetic retinopathy (DR), as microvascular complications of diabetes mellitus, are currently the leading causes of end-stage renal disease (ESRD) and blindness, respectively, in the adult working population, and they are major public health problems with social and eco...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1336123/full |
| _version_ | 1827351341692878848 |
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| author | Shanshan Tang Xuedong An Wenjie Sun Yuehong Zhang Cunqing Yang Xiaomin Kang Yuting Sun Linlin Jiang Xuefei Zhao Qing Gao Hangyu Ji Fengmei Lian |
| author_facet | Shanshan Tang Xuedong An Wenjie Sun Yuehong Zhang Cunqing Yang Xiaomin Kang Yuting Sun Linlin Jiang Xuefei Zhao Qing Gao Hangyu Ji Fengmei Lian |
| author_sort | Shanshan Tang |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) and diabetic retinopathy (DR), as microvascular complications of diabetes mellitus, are currently the leading causes of end-stage renal disease (ESRD) and blindness, respectively, in the adult working population, and they are major public health problems with social and economic burdens. The parallelism between the two in the process of occurrence and development manifests in the high overlap of disease-causing risk factors and pathogenesis, high rates of comorbidity, mutually predictive effects, and partial concordance in the clinical use of medications. However, since the two organs, the eye and the kidney, have their unique internal environment and physiological processes, each with specific influencing molecules, and the target organs have non-parallelism due to different pathological changes and responses to various influencing factors, this article provides an overview of the parallelism and non-parallelism between DN and DR to further recognize the commonalities and differences between the two diseases and provide references for early diagnosis, clinical guidance on the use of medication, and the development of new drugs. |
| first_indexed | 2024-03-08T02:02:45Z |
| format | Article |
| id | doaj.art-6e290ed01060478991119312f3a68cc1 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T02:02:45Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6e290ed01060478991119312f3a68cc12024-02-14T05:02:14ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.13361231336123Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathyShanshan Tang0Xuedong An1Wenjie Sun2Yuehong Zhang3Cunqing Yang4Xiaomin Kang5Yuting Sun6Linlin Jiang7Xuefei Zhao8Qing Gao9Hangyu Ji10Fengmei Lian11College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaFangshan Hospital, Beijing University of Chinese Medicine, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’an Men Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaDiabetic nephropathy (DN) and diabetic retinopathy (DR), as microvascular complications of diabetes mellitus, are currently the leading causes of end-stage renal disease (ESRD) and blindness, respectively, in the adult working population, and they are major public health problems with social and economic burdens. The parallelism between the two in the process of occurrence and development manifests in the high overlap of disease-causing risk factors and pathogenesis, high rates of comorbidity, mutually predictive effects, and partial concordance in the clinical use of medications. However, since the two organs, the eye and the kidney, have their unique internal environment and physiological processes, each with specific influencing molecules, and the target organs have non-parallelism due to different pathological changes and responses to various influencing factors, this article provides an overview of the parallelism and non-parallelism between DN and DR to further recognize the commonalities and differences between the two diseases and provide references for early diagnosis, clinical guidance on the use of medication, and the development of new drugs.https://www.frontiersin.org/articles/10.3389/fendo.2024.1336123/fulldiabetic retinopathydiabetic nephropathyparallelismnon-parallelismmechanism |
| spellingShingle | Shanshan Tang Xuedong An Wenjie Sun Yuehong Zhang Cunqing Yang Xiaomin Kang Yuting Sun Linlin Jiang Xuefei Zhao Qing Gao Hangyu Ji Fengmei Lian Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy Frontiers in Endocrinology diabetic retinopathy diabetic nephropathy parallelism non-parallelism mechanism |
| title | Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy |
| title_full | Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy |
| title_fullStr | Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy |
| title_full_unstemmed | Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy |
| title_short | Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy |
| title_sort | parallelism and non parallelism in diabetic nephropathy and diabetic retinopathy |
| topic | diabetic retinopathy diabetic nephropathy parallelism non-parallelism mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1336123/full |
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