miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1

miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1

Synapse loss is well regarded as the underlying cause for the progressive decline of memory function over the course of Alzheimer's disease (AD) development. Recent observations suggest that the accumulation of the Wnt antagonist Dickkopf-1 (Dkk1) in the AD brain plays a critical role in trigge...

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Bibliographic Details
Main Authors: Sean P. Ross, Kelly E. Baker, Amanda Fisher, Lee Hoff, Elena S. Pak, Alexander K. Murashov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
miRNA
amyloid-β
Kremen1
Dkk1
synaptic loss
Alzheimer's disease
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00087/full

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