The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients undergoing CABG with Cardiopulmonary Bypass
Abstract Objetive: Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) improved symptoms and increased survival and quality of life in patients with coronary artery disease. However, it should be the main cause of a complex organic systemic inflammatory response that greatly co...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382019000200156&lng=en&tlng=en |
| _version_ | 1817988511440044032 |
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| author | Marcos Antonio Cantero Rui Manuel Siqueira Almeida Priscila Neder Morato Valfredo de Almeida Santos-Junior Carolina Soares Moura Jaime Amaya-Farfan João Luis Fonseca Pablo Christiano Barboza Lollo |
| author_facet | Marcos Antonio Cantero Rui Manuel Siqueira Almeida Priscila Neder Morato Valfredo de Almeida Santos-Junior Carolina Soares Moura Jaime Amaya-Farfan João Luis Fonseca Pablo Christiano Barboza Lollo |
| author_sort | Marcos Antonio Cantero |
| collection | DOAJ |
| description | Abstract Objetive: Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) improved symptoms and increased survival and quality of life in patients with coronary artery disease. However, it should be the main cause of a complex organic systemic inflammatory response that greatly contributes to several postoperative adverse effects. Methods: We aimed to evaluate heat-shock protein 70 (HSP 70) expression as a morbimortality predictor in patients with preserved ventricular function undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and to determine their association with the lactate as a marker of tissue hypoperfusion and the EuroSCORE risk score. This is a prospective, observational study including 46 patients and occurring between May and July 2016. Patients without ventricular dysfunction undergoing myocardial revascularization with extracorporeal circulation were included. They were divided into (1) complicated and (2) uncomplicated postoperative evolution groups. EuroSCORE, lactate levels, and HSP 70 expression and their correlations were determined. Results: Statistical analysis showed that the group with complicated evolution had higher EuroSCORE values than the other group. HSP 70 protein levels were significantly increased in the group with uncomplicated evolution and showed similar results. According to our results, HSP family proteins may be independent predictors of uncomplicated evolution in patients without ventricular dysfunction undergoing CABG with CPB. Conclusion: HSP 70 should be a good discriminator and protection marker for complications in cardiac surgery. |
| first_indexed | 2024-04-14T00:35:49Z |
| format | Article |
| id | doaj.art-6e2951d05704473ea59424e8a6e994cc |
| institution | Directory Open Access Journal |
| issn | 1678-9741 |
| language | English |
| last_indexed | 2024-04-14T00:35:49Z |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-6e2951d05704473ea59424e8a6e994cc2022-12-22T02:22:23ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-974134215616410.21470/1678-9741-2018-0231S0102-76382019000200156The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients undergoing CABG with Cardiopulmonary BypassMarcos Antonio CanteroRui Manuel Siqueira AlmeidaPriscila Neder MoratoValfredo de Almeida Santos-JuniorCarolina Soares MouraJaime Amaya-FarfanJoão Luis FonsecaPablo Christiano Barboza LolloAbstract Objetive: Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) improved symptoms and increased survival and quality of life in patients with coronary artery disease. However, it should be the main cause of a complex organic systemic inflammatory response that greatly contributes to several postoperative adverse effects. Methods: We aimed to evaluate heat-shock protein 70 (HSP 70) expression as a morbimortality predictor in patients with preserved ventricular function undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and to determine their association with the lactate as a marker of tissue hypoperfusion and the EuroSCORE risk score. This is a prospective, observational study including 46 patients and occurring between May and July 2016. Patients without ventricular dysfunction undergoing myocardial revascularization with extracorporeal circulation were included. They were divided into (1) complicated and (2) uncomplicated postoperative evolution groups. EuroSCORE, lactate levels, and HSP 70 expression and their correlations were determined. Results: Statistical analysis showed that the group with complicated evolution had higher EuroSCORE values than the other group. HSP 70 protein levels were significantly increased in the group with uncomplicated evolution and showed similar results. According to our results, HSP family proteins may be independent predictors of uncomplicated evolution in patients without ventricular dysfunction undergoing CABG with CPB. Conclusion: HSP 70 should be a good discriminator and protection marker for complications in cardiac surgery.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382019000200156&lng=en&tlng=enHSP 70 Heat-Shock Proteins/BloodHeat-Shock ProteinsCoronary Artery BypassCardiopulmonary Bypass |
| spellingShingle | Marcos Antonio Cantero Rui Manuel Siqueira Almeida Priscila Neder Morato Valfredo de Almeida Santos-Junior Carolina Soares Moura Jaime Amaya-Farfan João Luis Fonseca Pablo Christiano Barboza Lollo The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients undergoing CABG with Cardiopulmonary Bypass Brazilian Journal of Cardiovascular Surgery HSP 70 Heat-Shock Proteins/Blood Heat-Shock Proteins Coronary Artery Bypass Cardiopulmonary Bypass |
| title | The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients undergoing CABG with Cardiopulmonary Bypass |
| title_full | The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients undergoing CABG with Cardiopulmonary Bypass |
| title_fullStr | The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients undergoing CABG with Cardiopulmonary Bypass |
| title_full_unstemmed | The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients undergoing CABG with Cardiopulmonary Bypass |
| title_short | The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients undergoing CABG with Cardiopulmonary Bypass |
| title_sort | expression of and preoperative correlation between heat shock protein 70 euroscore and lactate in patients undergoing cabg with cardiopulmonary bypass |
| topic | HSP 70 Heat-Shock Proteins/Blood Heat-Shock Proteins Coronary Artery Bypass Cardiopulmonary Bypass |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382019000200156&lng=en&tlng=en |
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