Exploring the significance of interleukin-33/ST2 axis in minimal change disease
Abstract Minimal change disease (MCD), a common cause of idiopathic nephrotic syndrome, has been postulated to exhibit an association with allergic conditions. Recent studies revealed the crucial role of interleukin (IL)-33 in type 2 innate immunity. We hypothesized that development of MCD involves...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-45678-z |
| _version_ | 1797453134822375424 |
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| author | Nobuhiro Kanazawa Masayuki Iyoda Taihei Suzuki Shohei Tachibana Ryuichi Nagashima Hirokazu Honda |
| author_facet | Nobuhiro Kanazawa Masayuki Iyoda Taihei Suzuki Shohei Tachibana Ryuichi Nagashima Hirokazu Honda |
| author_sort | Nobuhiro Kanazawa |
| collection | DOAJ |
| description | Abstract Minimal change disease (MCD), a common cause of idiopathic nephrotic syndrome, has been postulated to exhibit an association with allergic conditions. Recent studies revealed the crucial role of interleukin (IL)-33 in type 2 innate immunity. We hypothesized that development of MCD involves an IL-33–related immune response. We examined 49 patients with biopsy-proven MCD, 6 healthy volunteers, and 29 patients in remission. In addition to clinical features, serum and urinary levels of IL-33 and soluble suppression of tumorigenicity 2 protein (sST2), a secreted form of the receptor of IL-33, were analyzed. Although IL-33 was barely detectable in either MCD or control samples, sST2 levels at diagnosis were elevated in MCD patients. Serum sST2 levels of MCD patients were correlated with serum total protein level (r = − 0.36, p = 0.010) and serum creatinine level (r = 0.34, p = 0.016). Furthermore, the elevated sST2 levels were observed to decrease following remission. Immunofluorescence revealed IL-33 expression in the podocytes among MCD patients, with a significant increase compared with controls. In vitro, mouse podocyte cells incubated with serum from a MCD patient at disease onset showed increased IL-33 secretion. These results suggest an IL-33–related immune response plays a role in MCD. |
| first_indexed | 2024-03-09T15:18:32Z |
| format | Article |
| id | doaj.art-6e2a60698ce84e67b1cc7651bde235b4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:18:32Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6e2a60698ce84e67b1cc7651bde235b42023-11-26T12:56:46ZengNature PortfolioScientific Reports2045-23222023-10-011311910.1038/s41598-023-45678-zExploring the significance of interleukin-33/ST2 axis in minimal change diseaseNobuhiro Kanazawa0Masayuki Iyoda1Taihei Suzuki2Shohei Tachibana3Ryuichi Nagashima4Hirokazu Honda5Division of Nephrology, Department of Medicine, Showa University School of MedicineDivision of Nephrology, Department of Medicine, Showa University School of MedicineDivision of Nephrology, Department of Medicine, Showa University School of MedicineDivision of Nephrology, Department of Medicine, Showa University School of MedicineDepartment of Microbiology and Immunology, Showa University School of MedicineDivision of Nephrology, Department of Medicine, Showa University School of MedicineAbstract Minimal change disease (MCD), a common cause of idiopathic nephrotic syndrome, has been postulated to exhibit an association with allergic conditions. Recent studies revealed the crucial role of interleukin (IL)-33 in type 2 innate immunity. We hypothesized that development of MCD involves an IL-33–related immune response. We examined 49 patients with biopsy-proven MCD, 6 healthy volunteers, and 29 patients in remission. In addition to clinical features, serum and urinary levels of IL-33 and soluble suppression of tumorigenicity 2 protein (sST2), a secreted form of the receptor of IL-33, were analyzed. Although IL-33 was barely detectable in either MCD or control samples, sST2 levels at diagnosis were elevated in MCD patients. Serum sST2 levels of MCD patients were correlated with serum total protein level (r = − 0.36, p = 0.010) and serum creatinine level (r = 0.34, p = 0.016). Furthermore, the elevated sST2 levels were observed to decrease following remission. Immunofluorescence revealed IL-33 expression in the podocytes among MCD patients, with a significant increase compared with controls. In vitro, mouse podocyte cells incubated with serum from a MCD patient at disease onset showed increased IL-33 secretion. These results suggest an IL-33–related immune response plays a role in MCD.https://doi.org/10.1038/s41598-023-45678-z |
| spellingShingle | Nobuhiro Kanazawa Masayuki Iyoda Taihei Suzuki Shohei Tachibana Ryuichi Nagashima Hirokazu Honda Exploring the significance of interleukin-33/ST2 axis in minimal change disease Scientific Reports |
| title | Exploring the significance of interleukin-33/ST2 axis in minimal change disease |
| title_full | Exploring the significance of interleukin-33/ST2 axis in minimal change disease |
| title_fullStr | Exploring the significance of interleukin-33/ST2 axis in minimal change disease |
| title_full_unstemmed | Exploring the significance of interleukin-33/ST2 axis in minimal change disease |
| title_short | Exploring the significance of interleukin-33/ST2 axis in minimal change disease |
| title_sort | exploring the significance of interleukin 33 st2 axis in minimal change disease |
| url | https://doi.org/10.1038/s41598-023-45678-z |
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