Surface-Mediated Modulation of Different Biological Responses on Anatase-Coated Titanium
Various surface modification strategies are being developed to endow dental titanium implant surfaces with micro- and nano-structures to improve their biocompatibility, and first of all their osseointegration. These modifications have the potential to address clinical concerns by stimulating differe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/2/29 |
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| author | Leila Mohammadnejad Antonia Theurer Julia Alber Barbara Illing Evi Kimmerle-Mueller Jacob Schultheiss Stefanie Krajewski Frank Rupp |
| author_facet | Leila Mohammadnejad Antonia Theurer Julia Alber Barbara Illing Evi Kimmerle-Mueller Jacob Schultheiss Stefanie Krajewski Frank Rupp |
| author_sort | Leila Mohammadnejad |
| collection | DOAJ |
| description | Various surface modification strategies are being developed to endow dental titanium implant surfaces with micro- and nano-structures to improve their biocompatibility, and first of all their osseointegration. These modifications have the potential to address clinical concerns by stimulating different biological processes. This study aims to evaluate the biological responses of ananatase-modified blasted/etched titanium (SLA-anatase) surfaces compared to blasted/acid etched (SLA) and machined titanium surfaces. Using unipolar pulsed direct current (DC) sputtering, a nanocrystalline anatase layer was fabricated. In vitro experiments have shown that SLA-anatase discs can effectively promote osteoblast adhesion and proliferation, which are regarded as important features of a successful dental implant with bone contact. Furthermore, anatase surface modification has been shown to partially enhance osteoblast mineralization in vitro, while not significantly affecting bacterial colonization. Consequently, the recently created anatase coating holds significant potential as a promising candidate for future advancements in dental implant surface modification for improving the initial stages of osseointegration. |
| first_indexed | 2024-03-07T22:26:42Z |
| format | Article |
| id | doaj.art-6e2c55ffe730429e8a3138352a7141db |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-07T22:26:42Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-6e2c55ffe730429e8a3138352a7141db2024-02-23T15:22:40ZengMDPI AGJournal of Functional Biomaterials2079-49832024-01-011522910.3390/jfb15020029Surface-Mediated Modulation of Different Biological Responses on Anatase-Coated TitaniumLeila Mohammadnejad0Antonia Theurer1Julia Alber2Barbara Illing3Evi Kimmerle-Mueller4Jacob Schultheiss5Stefanie Krajewski6Frank Rupp7Department Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, GermanyDepartment Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, GermanyDepartment Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, GermanyDepartment Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, GermanyDepartment Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, GermanyDepartment Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, GermanyDepartment Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, GermanyDepartment Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, GermanyVarious surface modification strategies are being developed to endow dental titanium implant surfaces with micro- and nano-structures to improve their biocompatibility, and first of all their osseointegration. These modifications have the potential to address clinical concerns by stimulating different biological processes. This study aims to evaluate the biological responses of ananatase-modified blasted/etched titanium (SLA-anatase) surfaces compared to blasted/acid etched (SLA) and machined titanium surfaces. Using unipolar pulsed direct current (DC) sputtering, a nanocrystalline anatase layer was fabricated. In vitro experiments have shown that SLA-anatase discs can effectively promote osteoblast adhesion and proliferation, which are regarded as important features of a successful dental implant with bone contact. Furthermore, anatase surface modification has been shown to partially enhance osteoblast mineralization in vitro, while not significantly affecting bacterial colonization. Consequently, the recently created anatase coating holds significant potential as a promising candidate for future advancements in dental implant surface modification for improving the initial stages of osseointegration.https://www.mdpi.com/2079-4983/15/2/29anatasedental implantosseointegrationfibroblast |
| spellingShingle | Leila Mohammadnejad Antonia Theurer Julia Alber Barbara Illing Evi Kimmerle-Mueller Jacob Schultheiss Stefanie Krajewski Frank Rupp Surface-Mediated Modulation of Different Biological Responses on Anatase-Coated Titanium Journal of Functional Biomaterials anatase dental implant osseointegration fibroblast |
| title | Surface-Mediated Modulation of Different Biological Responses on Anatase-Coated Titanium |
| title_full | Surface-Mediated Modulation of Different Biological Responses on Anatase-Coated Titanium |
| title_fullStr | Surface-Mediated Modulation of Different Biological Responses on Anatase-Coated Titanium |
| title_full_unstemmed | Surface-Mediated Modulation of Different Biological Responses on Anatase-Coated Titanium |
| title_short | Surface-Mediated Modulation of Different Biological Responses on Anatase-Coated Titanium |
| title_sort | surface mediated modulation of different biological responses on anatase coated titanium |
| topic | anatase dental implant osseointegration fibroblast |
| url | https://www.mdpi.com/2079-4983/15/2/29 |
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