Enantioselective Synthesis of Oxazocines via MQ‐Phos Enabled Palladium‐Catalyzed Asymmetric Formal [4+4]‐Cycloadditions

Enantioselective Synthesis of Oxazocines via MQ‐Phos Enabled Palladium‐Catalyzed Asymmetric Formal [4+4]‐Cycloadditions

Abstract Oxazocines are key structural intermediates in the synthesis of natural products and pharmaceutical molecules. However, the synthesis of oxazocines especially in a highly enantioselective manner, is a long‐standing formidable challenge due to unfavorable energetics involved in cyclization....

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Hlavní autoři: Qiaojing Meng, Yinggao Meng, Qinglin Liu, Bing Yu, Zhong‐Jun Li, Er‐Qing Li, Junliang Zhang
Médium: Článek
Jazyk:English
Vydáno: Wiley 2024-08-01
Edice:Advanced Science
Témata:
[4+4]‐cycloaddition
enantioselectivity
medium‐sized ring
MQ‐Phos ligand
palladium catalysis
On-line přístup:https://doi.org/10.1002/advs.202402170

Internet

https://doi.org/10.1002/advs.202402170

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