Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications
The main aim of the current study is to fabricate an osteocompatible, bioactive, porous, and degradable bone tissue engineering scaffold. For this purpose, bioactive glasses (BGs) were chosen due to their similarity to bone’s natural mineral composition, and the effect of replacing Ca ions with Sr o...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/10/1472 |
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| author | Soheila Zare Mahnaz Mohammadpour Zhila Izadi Samaneh Ghazanfari Samad Nadri Hadi Samadian |
| author_facet | Soheila Zare Mahnaz Mohammadpour Zhila Izadi Samaneh Ghazanfari Samad Nadri Hadi Samadian |
| author_sort | Soheila Zare |
| collection | DOAJ |
| description | The main aim of the current study is to fabricate an osteocompatible, bioactive, porous, and degradable bone tissue engineering scaffold. For this purpose, bioactive glasses (BGs) were chosen due to their similarity to bone’s natural mineral composition, and the effect of replacing Ca ions with Sr on their properties were considered. First, strontium-containing BGs (Sr-BGs) were synthesized using the electrospinning technique and assembled by the sol–gel method, then they were incorporated into the alginate (Alg) matrix. Photographs of the scanning electron microscope (SEM) showed that the BG nanofibers have a diameter of 220 ± 36 nm, which was smaller than the precursor nanofibers (275 ± 66 nm). The scaffolds possess a porous internal microstructure (230–330 nm pore size) with interconnected pores. We demonstrated that the scaffolds could be degraded in the acetate sodium buffer and phosphate-buffered saline. The osteoactivity of the scaffolds was confirmed via visual inspection of the SEM illustrations after seven days of immersing them in the SBF solution. In vitro assessments disclosed that the produced Alg-based composites including Sr-BGs (Alg/Sr-BGs) are blood-compatible and biocompatible. Accumulating evidence shows that Alg/Sr-BG (5%, 10%, and 15%) hydrogels could be a promising scaffold for bone regeneration. |
| first_indexed | 2024-03-09T20:39:52Z |
| format | Article |
| id | doaj.art-6e2fa097b4574712a963743030f8dc48 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T20:39:52Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-6e2fa097b4574712a963743030f8dc482023-11-23T23:00:08ZengMDPI AGBiology2079-77372022-10-011110147210.3390/biology11101472Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering ApplicationsSoheila Zare0Mahnaz Mohammadpour1Zhila Izadi2Samaneh Ghazanfari3Samad Nadri4Hadi Samadian5Student Research Committee, Zanjan University of Medical Sciences, Zanjan 45154, IranDepartment of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran 1411713116, IranPharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah P.O. Box 671551616, IranAachen-Maastricht Institute for Biobased Materials (AMIBM), Faculty of Science and Engineering, Maastricht University, 6167 RD Geleen, The NetherlandsZanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 45154, IranResearch Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan 6517838736, IranThe main aim of the current study is to fabricate an osteocompatible, bioactive, porous, and degradable bone tissue engineering scaffold. For this purpose, bioactive glasses (BGs) were chosen due to their similarity to bone’s natural mineral composition, and the effect of replacing Ca ions with Sr on their properties were considered. First, strontium-containing BGs (Sr-BGs) were synthesized using the electrospinning technique and assembled by the sol–gel method, then they were incorporated into the alginate (Alg) matrix. Photographs of the scanning electron microscope (SEM) showed that the BG nanofibers have a diameter of 220 ± 36 nm, which was smaller than the precursor nanofibers (275 ± 66 nm). The scaffolds possess a porous internal microstructure (230–330 nm pore size) with interconnected pores. We demonstrated that the scaffolds could be degraded in the acetate sodium buffer and phosphate-buffered saline. The osteoactivity of the scaffolds was confirmed via visual inspection of the SEM illustrations after seven days of immersing them in the SBF solution. In vitro assessments disclosed that the produced Alg-based composites including Sr-BGs (Alg/Sr-BGs) are blood-compatible and biocompatible. Accumulating evidence shows that Alg/Sr-BG (5%, 10%, and 15%) hydrogels could be a promising scaffold for bone regeneration.https://www.mdpi.com/2079-7737/11/10/1472bone tissue engineeringhydrogelnanocompositebioglass nanofibersstrontium |
| spellingShingle | Soheila Zare Mahnaz Mohammadpour Zhila Izadi Samaneh Ghazanfari Samad Nadri Hadi Samadian Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications Biology bone tissue engineering hydrogel nanocomposite bioglass nanofibers strontium |
| title | Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications |
| title_full | Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications |
| title_fullStr | Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications |
| title_full_unstemmed | Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications |
| title_short | Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications |
| title_sort | nanofibrous hydrogel nanocomposite based on strontium doped bioglass nanofibers for bone tissue engineering applications |
| topic | bone tissue engineering hydrogel nanocomposite bioglass nanofibers strontium |
| url | https://www.mdpi.com/2079-7737/11/10/1472 |
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