Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters
The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain modulation system, and directly affects spinal nociceptive transmission through pronociceptive ON cells and antinociceptive OFF cells in this area. The functional status of ON and OFF neurons play a pivotal role in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1159753/full |
| _version_ | 1827963964497068032 |
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| author | Bingxue Peng Bingxue Peng Yingfu Jiao Yingfu Jiao Yunchun Zhang Yunchun Zhang Shian Li Shian Li Sihan Chen Sihan Chen Saihong Xu Saihong Xu Po Gao Po Gao Yinghui Fan Yinghui Fan Weifeng Yu Weifeng Yu |
| author_facet | Bingxue Peng Bingxue Peng Yingfu Jiao Yingfu Jiao Yunchun Zhang Yunchun Zhang Shian Li Shian Li Sihan Chen Sihan Chen Saihong Xu Saihong Xu Po Gao Po Gao Yinghui Fan Yinghui Fan Weifeng Yu Weifeng Yu |
| author_sort | Bingxue Peng |
| collection | DOAJ |
| description | The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain modulation system, and directly affects spinal nociceptive transmission through pronociceptive ON cells and antinociceptive OFF cells in this area. The functional status of ON and OFF neurons play a pivotal role in pain chronification. As distinct pain modulative information converges in the RVM and affects ON and OFF cell excitability, neural circuits and transmitters correlated to RVM need to be defined for an in-depth understanding of central-mediated pain sensitivity. In this review, neural circuits including the role of the periaqueductal gray, locus coeruleus, parabrachial complex, hypothalamus, amygdala input to the RVM, and RVM output to the spinal dorsal horn are discussed. Meanwhile, the role of neurotransmitters is concluded, including serotonin, opioids, amino acids, cannabinoids, TRPV1, substance P and cholecystokinin, and their dynamic impact on both ON and OFF cell activities in modulating pain transmission. Via clarifying potential specific receptors of ON and OFF cells, more targeted therapies can be raised to generate pain relief for patients who suffer from chronic pain. |
| first_indexed | 2024-04-09T17:07:40Z |
| format | Article |
| id | doaj.art-6e2fa7758eb149c8aa958a1a47a88c10 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T17:07:40Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-6e2fa7758eb149c8aa958a1a47a88c102023-04-20T10:25:36ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11597531159753Bulbospinal nociceptive ON and OFF cells related neural circuits and transmittersBingxue Peng0Bingxue Peng1Yingfu Jiao2Yingfu Jiao3Yunchun Zhang4Yunchun Zhang5Shian Li6Shian Li7Sihan Chen8Sihan Chen9Saihong Xu10Saihong Xu11Po Gao12Po Gao13Yinghui Fan14Yinghui Fan15Weifeng Yu16Weifeng Yu17Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, ChinaThe rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain modulation system, and directly affects spinal nociceptive transmission through pronociceptive ON cells and antinociceptive OFF cells in this area. The functional status of ON and OFF neurons play a pivotal role in pain chronification. As distinct pain modulative information converges in the RVM and affects ON and OFF cell excitability, neural circuits and transmitters correlated to RVM need to be defined for an in-depth understanding of central-mediated pain sensitivity. In this review, neural circuits including the role of the periaqueductal gray, locus coeruleus, parabrachial complex, hypothalamus, amygdala input to the RVM, and RVM output to the spinal dorsal horn are discussed. Meanwhile, the role of neurotransmitters is concluded, including serotonin, opioids, amino acids, cannabinoids, TRPV1, substance P and cholecystokinin, and their dynamic impact on both ON and OFF cell activities in modulating pain transmission. Via clarifying potential specific receptors of ON and OFF cells, more targeted therapies can be raised to generate pain relief for patients who suffer from chronic pain.https://www.frontiersin.org/articles/10.3389/fphar.2023.1159753/fullrostral ventromedial medullapainneural circuittransmitterON cellOFF cell |
| spellingShingle | Bingxue Peng Bingxue Peng Yingfu Jiao Yingfu Jiao Yunchun Zhang Yunchun Zhang Shian Li Shian Li Sihan Chen Sihan Chen Saihong Xu Saihong Xu Po Gao Po Gao Yinghui Fan Yinghui Fan Weifeng Yu Weifeng Yu Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters Frontiers in Pharmacology rostral ventromedial medulla pain neural circuit transmitter ON cell OFF cell |
| title | Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters |
| title_full | Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters |
| title_fullStr | Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters |
| title_full_unstemmed | Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters |
| title_short | Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters |
| title_sort | bulbospinal nociceptive on and off cells related neural circuits and transmitters |
| topic | rostral ventromedial medulla pain neural circuit transmitter ON cell OFF cell |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1159753/full |
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