Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters

Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters

The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain modulation system, and directly affects spinal nociceptive transmission through pronociceptive ON cells and antinociceptive OFF cells in this area. The functional status of ON and OFF neurons play a pivotal role in...

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Bibliographic Details
Main Authors: Bingxue Peng, Yingfu Jiao, Yunchun Zhang, Shian Li, Sihan Chen, Saihong Xu, Po Gao, Yinghui Fan, Weifeng Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
rostral ventromedial medulla
pain
neural circuit
transmitter
ON cell
OFF cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1159753/full

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