Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models

Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models

PI3K pathway activation is frequently observed in triple negative breast cancer (TNBC). However, single agent PI3K inhibitors have shown limited anti-tumor activity. To investigate biomarkers of response and resistance mechanisms, we tested 17 TNBC patient-derived xenograft (PDX) models representing...

Full description

Bibliographic Details
Main Authors:	Zhanfang Guo, Tina Primeau, Jingqin Luo, Cynthia Zhang, Hua Sun, Jeremy Hoog, Feng Gao, Shixia Huang, Dean P. Edwards, Sherri R. Davies, Rebecca Aft, Li Ding, Matthew J. Ellis, Shunqiang Li, Cynthia X. Ma
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Cancers
Subjects:	biomarkers PI3K inhibitor BKM120 triple negative breast cancer patient-derived xenograft
Online Access:	https://www.mdpi.com/2072-6694/12/12/3857

Similar Items

Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer
by: Ana C. Garrido-Castro, et al.
Published: (2020-11-01)

Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy
by: Xin Peng, et al.
Published: (2021-11-01)

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy
by: Achira Roy, et al.
Published: (2015-12-01)

Orthotopic Patient-Derived Xenografts of Gastric Cancer to Decipher Drugs Effects on Cancer Stem Cells and Metastatic Dissemination
by: Julie Giraud, et al.
Published: (2019-04-01)

Positive Effects of PI3K/Akt Signaling Inhibition on PTEN and P53 in Prevention of Acute Lymphoblastic Leukemia Tumor Cells
by: Elahe Naderali, et al.
Published: (2019-08-01)

Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA-Driven Intractable Epilepsy
by: Achira Roy, et al.
Published: (2021-11-01)

Apoptin Overexpression Efficiently Amplified Cytotoxic Effects of PI3K Inhibition Using BKM120 in Lymphoblastic Leukemia Cell Lines
by: Ali Anjam-Najmedini, et al.
Published: (2022-05-01)

PI3K Abrogation Using Pan-PI3K Inhibitor BKM120 Gives Rise to a Significant Anticancer Effect on AML-Derived KG-1 Cells by Inducing Apoptosis and G2/M Arrest
by: Soroush Sadeghi, et al.
Published: (2020-08-01)

Synergistic Antitumor Effect of BKM120 with Prima-1Met Via Inhibiting PI3K/AKT/mTOR and CPSF4/hTERT Signaling and Reactivating Mutant P53
by: Zongjuan Li, et al.
Published: (2018-02-01)

Pesticide Toxicity Profile: Chlorophenoxy Herbicides
by: Frederick M. Fishel
Published: (2005-12-01)

Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer
by: Cameron N. Johnstone, et al.
Published: (2018-05-01)

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model
by: Margarite D. Matossian, et al.
Published: (2019-03-01)

Translation of triple-negative breast cancer behavior from the xenograft model to human model
by: Sanaz Rismanchi, et al.
Published: (2016-11-01)

Perencanaan Keuangan Keluarga untuk Anggota BKM Unggul Jaya Pecangaan Kulon, Jepara
by: Faiqul Hazmi, et al.
Published: (2019-10-01)

Analisis Akuntabilitas dan Transparansi Pengelolaan Dana Pnpm Mandiri Pada Badan Keswadayaan Masyarakat Betul Kota Malang
by: Vivi Dwi Aryanti, et al.
Published: (2016-03-01)

Molecular Investigation on a Triple Negative Breast Cancer Xenograft Model Exposed to Proton Beams
by: Francesco P. Cammarata, et al.
Published: (2020-09-01)

Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models
by: Rachel A. Sabol, et al.
Published: (2019-05-01)

Identifying biomarkers of breast cancer micrometastatic disease in bone marrow using a patient-derived xenograft mouse model
by: Sreeraj G. Pillai, et al.
Published: (2018-01-01)

The Development of Islamic Religious Education at The Prosperity Agency of The Mosque (BKM) At-Taqwa University of Medan Area
by: Rizki Ananda, et al.
Published: (2021-10-01)

Türk Yapım Şirketlerinin Görsel Kimlik Bağlamında İncelenmesi: BKM Örneği
by: Özer Silsüpür, et al.
Published: (2021-10-01)

Impact of the Pd<sub>2</sub>Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model
by: Tatiana J. Carneiro, et al.
Published: (2021-10-01)

Patient-Derived Xenografts as an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer
by: Margarite D. Matossian, et al.
Published: (2020-09-01)

Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4’-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2’-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers
by: Tzu-Chun Kan, et al.
Published: (2022-04-01)

EFFECTS OF FUNGAL TREATMENT ON STRUCTURAL AND CHEMICAL FEATURES OF HORNBEAM CHIPS
by: Mohammad Talaeipour, et al.
Published: (2010-02-01)

Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts
by: Chia-Yu Yang, et al.
Published: (2020-06-01)

Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway
by: Daoyu Zhang, et al.
Published: (2020-10-01)

ÍNDICES DE INTEMPERISMO E EVOLUÇÃO DOS PALEOSSOLOS DA FORMAÇÃO MARÍLIA, MAASTRICHTIANO DA BACIA NEOCRETÁCEA BAURU
by: Márcio Luiz Silva, et al.
Published: (2016-05-01)

Development of a Triple-Negative Breast Cancer Leptomeningeal Disease Model in Zebrafish
by: Udhayakumar Gopal, et al.
Published: (2023-03-01)

Fangjihuangqi Decoction inhibits MDA‐MB‐231 cell invasion in vitro and decreases tumor growth and metastasis in triple‐negative breast cancer xenografts tumor zebrafish model
by: Yubo Guo, et al.
Published: (2020-04-01)

[6]-Gingerol-Derived Semi-Synthetic Compound SSi6 Inhibits Tumor Growth and Metastatic Dissemination in Triple-Negative Breast Cancer Xenograft Models
by: Liany Luna-Dulcey, et al.
Published: (2021-06-01)

Deep Learning Segmentation of Triple-Negative Breast Cancer (TNBC) Patient Derived Tumor Xenograft (PDX) and Sensitivity of Radiomic Pipeline to Tumor Probability Boundary
by: Kaushik Dutta, et al.
Published: (2021-07-01)

Diagnostics of HNSCC Patients: An Analysis of Cell Lines and Patient-Derived Xenograft Models for Personalized Therapeutical Medicine
by: Ramona Gabriela Ursu, et al.
Published: (2022-04-01)

Osthole inhibits triple negative breast cancer cells by suppressing STAT3
by: Xuanxuan Dai, et al.
Published: (2018-12-01)

Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer
by: Jeremy Johnson, et al.
Published: (2020-05-01)

Orally Administered Halofuginone-Loaded TPGS Polymeric Micelles Against Triple-Negative Breast Cancer: Enhanced Absorption and Efficacy with Reduced Toxicity and Metastasis
by: Zuo R, et al.
Published: (2022-05-01)

Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model
by: Claudia Tulotta, et al.
Published: (2016-02-01)

Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models
by: Valentina Belli, et al.
Published: (2019-06-01)

Bone Xenografts in Trauma and Orthopaedics (Analytical Review)
by: M. V. Stogov, et al.
Published: (2020-03-01)

Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases
by: María J. Contreras-Zárate, et al.
Published: (2017-11-01)

Regression of Triple-Negative Breast Cancer in a Patient-Derived Xenograft Mouse Model by Monoclonal Antibodies against IL-12 p40 Monomer
by: Madhuchhanda Kundu, et al.
Published: (2022-01-01)