Balancing proliferation with Igκ recombination during B lymphopoiesis

Balancing proliferation with Igκ recombination during B lymphopoiesis

The essential events of B-cell development are the stochastic and sequential rearrangement of immunoglobulin heavy (Igμ) and then light chain (Igκ followed by Igλ) loci. The counterpoint to recombination is proliferation, which both maintains populations of pro-B cells undergoing Igμ recombination...

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Bibliographic Details
Main Authors: Keith Michael Hamel, Malay eMandal, Sophiya eKarki, Marcus R Clark
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Immunology
Subjects:
Lymphopoiesis
epigenetics
recombination
proliferation
B-cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00139/full

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