Emerging role of IκBζ in inflammation: Emphasis on psoriasis
Abstract Psoriasis is a chronic inflammatory disorder affecting skin and joints that results from immunological dysfunction such as enhanced IL‐23 induced Th‐17 differentiation. IkappaB‐Zeta (IκBζ) is an atypical transcriptional factor of the IκB protein family since, contrary to the other family me...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctm2.1032 |
| _version_ | 1797988904702312448 |
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| author | Preeti Gautam Sylvain Maenner Frédéric Cailotto Pascal Reboul Stéphane Labialle Jean‐Yves Jouzeau Frédéric Bourgaud David Moulin |
| author_facet | Preeti Gautam Sylvain Maenner Frédéric Cailotto Pascal Reboul Stéphane Labialle Jean‐Yves Jouzeau Frédéric Bourgaud David Moulin |
| author_sort | Preeti Gautam |
| collection | DOAJ |
| description | Abstract Psoriasis is a chronic inflammatory disorder affecting skin and joints that results from immunological dysfunction such as enhanced IL‐23 induced Th‐17 differentiation. IkappaB‐Zeta (IκBζ) is an atypical transcriptional factor of the IκB protein family since, contrary to the other family members, it positively regulates NF‐κB pathway by being exclusively localized into the nucleus. IκBζ deficiency reduces visible manifestations of experimental psoriasis by diminishing expression of psoriasis‐associated genes. It is thus tempting to consider IκBζ as a potential therapeutic target for psoriasis as well as for other IL23/IL17‐mediated inflammatory diseases. In this review, we will discuss the regulation of expression of NFKBIZ and its protein IκBζ, its downstream targets, its involvement in pathogenesis of multiple disorders with emphasis on psoriasis and evidences supporting that inhibition of IκBζ may be a promising alternative to current therapeutic managements of psoriasis. |
| first_indexed | 2024-04-11T08:11:34Z |
| format | Article |
| id | doaj.art-6e3061e5bae947cc9214460e37c13b23 |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-04-11T08:11:34Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-6e3061e5bae947cc9214460e37c13b232022-12-22T04:35:21ZengWileyClinical and Translational Medicine2001-13262022-10-011210n/an/a10.1002/ctm2.1032Emerging role of IκBζ in inflammation: Emphasis on psoriasisPreeti Gautam0Sylvain Maenner1Frédéric Cailotto2Pascal Reboul3Stéphane Labialle4Jean‐Yves Jouzeau5Frédéric Bourgaud6David Moulin7Laboratoire IMoPA UMR 7365 CNRS‐Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre‐lès‐Nancy FranceLaboratoire IMoPA UMR 7365 CNRS‐Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre‐lès‐Nancy FranceLaboratoire IMoPA UMR 7365 CNRS‐Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre‐lès‐Nancy FranceLaboratoire IMoPA UMR 7365 CNRS‐Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre‐lès‐Nancy FranceLaboratoire IMoPA UMR 7365 CNRS‐Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre‐lès‐Nancy FranceLaboratoire IMoPA UMR 7365 CNRS‐Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre‐lès‐Nancy FranceTemisis Therapeutics Vandœuvre‐lès‐Nancy FranceLaboratoire IMoPA UMR 7365 CNRS‐Université de Lorraine, Biopôle de l'Université de Lorraine Vandœuvre‐lès‐Nancy FranceAbstract Psoriasis is a chronic inflammatory disorder affecting skin and joints that results from immunological dysfunction such as enhanced IL‐23 induced Th‐17 differentiation. IkappaB‐Zeta (IκBζ) is an atypical transcriptional factor of the IκB protein family since, contrary to the other family members, it positively regulates NF‐κB pathway by being exclusively localized into the nucleus. IκBζ deficiency reduces visible manifestations of experimental psoriasis by diminishing expression of psoriasis‐associated genes. It is thus tempting to consider IκBζ as a potential therapeutic target for psoriasis as well as for other IL23/IL17‐mediated inflammatory diseases. In this review, we will discuss the regulation of expression of NFKBIZ and its protein IκBζ, its downstream targets, its involvement in pathogenesis of multiple disorders with emphasis on psoriasis and evidences supporting that inhibition of IκBζ may be a promising alternative to current therapeutic managements of psoriasis.https://doi.org/10.1002/ctm2.1032psoriasisikappabZeta, IκBζinflammationNFKBIZ |
| spellingShingle | Preeti Gautam Sylvain Maenner Frédéric Cailotto Pascal Reboul Stéphane Labialle Jean‐Yves Jouzeau Frédéric Bourgaud David Moulin Emerging role of IκBζ in inflammation: Emphasis on psoriasis Clinical and Translational Medicine psoriasis ikappabZeta, IκBζ inflammation NFKBIZ |
| title | Emerging role of IκBζ in inflammation: Emphasis on psoriasis |
| title_full | Emerging role of IκBζ in inflammation: Emphasis on psoriasis |
| title_fullStr | Emerging role of IκBζ in inflammation: Emphasis on psoriasis |
| title_full_unstemmed | Emerging role of IκBζ in inflammation: Emphasis on psoriasis |
| title_short | Emerging role of IκBζ in inflammation: Emphasis on psoriasis |
| title_sort | emerging role of iκbζ in inflammation emphasis on psoriasis |
| topic | psoriasis ikappabZeta, IκBζ inflammation NFKBIZ |
| url | https://doi.org/10.1002/ctm2.1032 |
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