Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis
Abstract N‐acetyl‐cysteine (NAC) is an efficacious treatment for sensorineural hearing loss in animal models, such as noise‐induced hearing loss (NIHL), however previous research into the effect of NAC on patients with hearing loss produced contradictory results. In this study, we investigated the e...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.wjorl.2021.01.005 |
| _version_ | 1811177998172291072 |
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| author | Xue Bai Miao Wang Xun Niu Hong Yu Jian‐Xin Yue Yu Sun |
| author_facet | Xue Bai Miao Wang Xun Niu Hong Yu Jian‐Xin Yue Yu Sun |
| author_sort | Xue Bai |
| collection | DOAJ |
| description | Abstract N‐acetyl‐cysteine (NAC) is an efficacious treatment for sensorineural hearing loss in animal models, such as noise‐induced hearing loss (NIHL), however previous research into the effect of NAC on patients with hearing loss produced contradictory results. In this study, we investigated the effect of NAC treatment on sensorineural hearing loss. PubMed, Web of Science and Embase databases were searched in their entirety using the key words: hearing loss, NAC, N‐acetylcysteine, and sensorineural hearing loss. Studies which included assessment of hearing loss with pure‐tone threshold (PTA) data were selected. Eligible studies regarding the effects of NAC treatment on patients with hearing loss were collected by two independent reviewers. A total of 1197 individuals were included from seven published studies. Two studies reported data for a sudden idiopathic sensorineural hearing loss (SISNHL) group. Three studies reported data for a NIHL group. Other studies reported data for drug‐induced hearing loss. The meta‐analysis demonstrated that the overall effect of NAC treatment on sensorineural hearing loss was invalid. However, NAC treatment was linked with improved patient outcomes of hearing tests in cases of sudden hearing loss, but did not prevent hearing loss induced by noise or ototoxicity. However, there is a need for better‐designed studies with larger samples to further prove the correlation between the effect of NAC and hearing loss. |
| first_indexed | 2024-04-11T06:10:52Z |
| format | Article |
| id | doaj.art-6e31306da07f486d8543a145e1761453 |
| institution | Directory Open Access Journal |
| issn | 2095-8811 2589-1081 |
| language | English |
| last_indexed | 2024-04-11T06:10:52Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| spelling | doaj.art-6e31306da07f486d8543a145e17614532022-12-22T04:41:16ZengWileyWorld Journal of Otorhinolaryngology-Head and Neck Surgery2095-88112589-10812022-09-018320521210.1016/j.wjorl.2021.01.005Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysisXue Bai0Miao Wang1Xun Niu2Hong Yu3Jian‐Xin Yue4Yu Sun5Department of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 ChinaAbstract N‐acetyl‐cysteine (NAC) is an efficacious treatment for sensorineural hearing loss in animal models, such as noise‐induced hearing loss (NIHL), however previous research into the effect of NAC on patients with hearing loss produced contradictory results. In this study, we investigated the effect of NAC treatment on sensorineural hearing loss. PubMed, Web of Science and Embase databases were searched in their entirety using the key words: hearing loss, NAC, N‐acetylcysteine, and sensorineural hearing loss. Studies which included assessment of hearing loss with pure‐tone threshold (PTA) data were selected. Eligible studies regarding the effects of NAC treatment on patients with hearing loss were collected by two independent reviewers. A total of 1197 individuals were included from seven published studies. Two studies reported data for a sudden idiopathic sensorineural hearing loss (SISNHL) group. Three studies reported data for a NIHL group. Other studies reported data for drug‐induced hearing loss. The meta‐analysis demonstrated that the overall effect of NAC treatment on sensorineural hearing loss was invalid. However, NAC treatment was linked with improved patient outcomes of hearing tests in cases of sudden hearing loss, but did not prevent hearing loss induced by noise or ototoxicity. However, there is a need for better‐designed studies with larger samples to further prove the correlation between the effect of NAC and hearing loss.https://doi.org/10.1016/j.wjorl.2021.01.005Hearing lossMeta‐analysisN‐acetyl‐cysteine |
| spellingShingle | Xue Bai Miao Wang Xun Niu Hong Yu Jian‐Xin Yue Yu Sun Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis World Journal of Otorhinolaryngology-Head and Neck Surgery Hearing loss Meta‐analysis N‐acetyl‐cysteine |
| title | Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis |
| title_full | Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis |
| title_fullStr | Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis |
| title_full_unstemmed | Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis |
| title_short | Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis |
| title_sort | effect of n acetyl cysteine treatment on sensorineural hearing loss a meta analysis |
| topic | Hearing loss Meta‐analysis N‐acetyl‐cysteine |
| url | https://doi.org/10.1016/j.wjorl.2021.01.005 |
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