THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION
Peritoneal adhesion occurs as a result of surgery, peritoneal injury, peritonitis, hypoxia, and ischemia. Surgical trauma causes many pathophysiological processes which include inflammation, oxidation, coagulation, fibrinolysis, cell proliferation, and apoptosis. After intra-abdominal operations, th...
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| Format: | Article |
| Language: | English |
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Trakya University
2023-10-01
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| Series: | Trakya University Journal of Natural Sciences |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/3185675 |
| _version_ | 1797633873420484608 |
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| author | Ece Miser Salihoğlu Gizem Deynez İpek Süntar |
| author_facet | Ece Miser Salihoğlu Gizem Deynez İpek Süntar |
| author_sort | Ece Miser Salihoğlu |
| collection | DOAJ |
| description | Peritoneal adhesion occurs as a result of surgery, peritoneal injury, peritonitis, hypoxia, and ischemia. Surgical trauma causes many pathophysiological processes which include inflammation, oxidation, coagulation, fibrinolysis, cell proliferation, and apoptosis. After intra-abdominal operations, the adhesion tissue may occur on the peritoneal surface due to low fibrinolytic activity. This may result in permanent excessive adhesion tissue bands instead of properly formed fibrin structures. Therefore, anticoagulant, thrombolytic, and fibrinolytic activities have a key role in preventing peritoneal adhesion. Indeed, several studies have been conducted to find out new and effective agents against intra-abdominal adhesion. Thus, revealing the causes, development processes, and investigation techniques are highly important for designing and conducting such scientific studies. In this context, this study aims to summarize the pathophysiological processes of above-mentioned activities and to emphasize their importance in the peritoneal adhesion model as well as to explain the evaluation methods, particularly in terms of the investigation of natural products. |
| first_indexed | 2024-03-11T12:00:46Z |
| format | Article |
| id | doaj.art-6e33599f21d74e58a202e17ae0cca42b |
| institution | Directory Open Access Journal |
| issn | 2528-9691 |
| language | English |
| last_indexed | 2024-03-11T12:00:46Z |
| publishDate | 2023-10-01 |
| publisher | Trakya University |
| record_format | Article |
| series | Trakya University Journal of Natural Sciences |
| spelling | doaj.art-6e33599f21d74e58a202e17ae0cca42b2023-11-08T07:27:55ZengTrakya UniversityTrakya University Journal of Natural Sciences2528-96912023-10-0124210111610.23902/trkjnat.130911969THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESIONEce Miser Salihoğlu0Gizem Deynez1İpek Süntar2GAZI UNIVERSITYGAZI UNIVERSITYGAZİ ÜNİVERSİTESİPeritoneal adhesion occurs as a result of surgery, peritoneal injury, peritonitis, hypoxia, and ischemia. Surgical trauma causes many pathophysiological processes which include inflammation, oxidation, coagulation, fibrinolysis, cell proliferation, and apoptosis. After intra-abdominal operations, the adhesion tissue may occur on the peritoneal surface due to low fibrinolytic activity. This may result in permanent excessive adhesion tissue bands instead of properly formed fibrin structures. Therefore, anticoagulant, thrombolytic, and fibrinolytic activities have a key role in preventing peritoneal adhesion. Indeed, several studies have been conducted to find out new and effective agents against intra-abdominal adhesion. Thus, revealing the causes, development processes, and investigation techniques are highly important for designing and conducting such scientific studies. In this context, this study aims to summarize the pathophysiological processes of above-mentioned activities and to emphasize their importance in the peritoneal adhesion model as well as to explain the evaluation methods, particularly in terms of the investigation of natural products.https://dergipark.org.tr/en/download/article-file/3185675adhesionanticoagulantpostoperative abdominal adhesionfibrinthrombincoagulationmedicinal plantsnatural products |
| spellingShingle | Ece Miser Salihoğlu Gizem Deynez İpek Süntar THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION Trakya University Journal of Natural Sciences adhesion anticoagulant postoperative abdominal adhesion fibrin thrombin coagulation medicinal plants natural products |
| title | THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION |
| title_full | THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION |
| title_fullStr | THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION |
| title_full_unstemmed | THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION |
| title_short | THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION |
| title_sort | role of anticoagulant thrombolytic and fibrinolytic activities in the prevention of peritoneal adhesion |
| topic | adhesion anticoagulant postoperative abdominal adhesion fibrin thrombin coagulation medicinal plants natural products |
| url | https://dergipark.org.tr/en/download/article-file/3185675 |
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