Evaluation of Poly(<i>N</i>-Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells

Evaluation of Poly(<i>N</i>-Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells

MicroRNAs (miRNAs) are endogenous, short RNA oligonucleotides that regulate the expression of hundreds of proteins to control cells’ function in physiological and pathological conditions. miRNA therapeutics are highly specific, reducing the toxicity associated with off-target effects, and require lo...

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Bibliographic Details
Main Authors: Altea Soto, Manuel Nieto-Díaz, Enrique Martínez-Campos, Ana Noalles-Dols, María Asunción Barreda-Manso, Felipe Reviriego, Helmut Reinecke, David Reigada, Teresa Muñoz-Galdeano, Irene Novillo, Alberto Gallardo, Juan Rodríguez-Hernández, Ramón Eritja, Anna Aviñó, Carlos Elvira, Rodrigo M. Maza
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceutics
Subjects:
poly (<i>N</i>-ethyl pyrrolidine methacrylamide)
polymeric delivery systems
miRNA transfection
neural cells
neurons
in vitro analyses
Online Access:https://www.mdpi.com/1999-4923/15/5/1451

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