Epidermolysis-Bullosa-Associated Squamous Cell Carcinomas Support an Immunosuppressive Tumor Microenvironment: Prospects for Immunotherapy

Epidermolysis-Bullosa-Associated Squamous Cell Carcinomas Support an Immunosuppressive Tumor Microenvironment: Prospects for Immunotherapy

Cutaneous squamous cell carcinomas (SCCs) are a major complication of some subtypes of epidermolysis bullosa (EB), with high morbidity and mortality rates and unmet therapeutic needs. The high rate of endogenous mutations and the fibrotic stroma are considered to contribute to the pathogenesis. Pati...

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Bibliographic Details
Main Authors: David Rafei-Shamsabadi, Lena Scholten, Sisi Lu, Daniele Castiglia, Giovanna Zambruno, Andreas Volz, Andreas Arnold, Mina Saleva, Ludovic Martin, Kristin Technau-Hafsi, Frank Meiss, Dagmar von Bubnoff, Cristina Has
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
epidermolysis bullosa
collagen VII
kindlin
squamous cell carcinoma
indoleamine 2,3-dioxygenase
programmed cell death protein-1
Online Access:https://www.mdpi.com/2072-6694/16/2/471

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