Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold

Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold

Abstract When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis and a fraction survives; if surviving cells are re‐exposed to TRAIL, fractional killing is once again observed. Therapeutic antibodies directed against TRAIL receptors also cause fractional killing, even a...

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Bibliographic Details
Main Authors: Jérémie Roux, Marc Hafner, Samuel Bandara, Joshua J Sims, Hannah Hudson, Diana Chai, Peter K Sorger
Format: Article
Language:English
Published: Springer Nature 2015-05-01
Series:Molecular Systems Biology
Subjects:
anti‐cancer therapeutic antibodies
apoptosis
DR4, DR5 receptors
programmed cell death
TRAIL
Online Access:https://doi.org/10.15252/msb.20145584

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