Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources
Diabetes mellitus (DM) is a common multifactorial disease, causing various complications, such as chronic metabolism. The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect. However, polysaccharides mainly extracted from natural resources,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000691 |
| _version_ | 1797695770481131520 |
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| author | Xiaolong Ji Jianhang Guo Tengzheng Cao Tingting Zhang Yanqi Liu Yizhe Yan |
| author_facet | Xiaolong Ji Jianhang Guo Tengzheng Cao Tingting Zhang Yanqi Liu Yizhe Yan |
| author_sort | Xiaolong Ji |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a common multifactorial disease, causing various complications, such as chronic metabolism. The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect. However, polysaccharides mainly extracted from natural resources, have advantages of safety, accessibility, and anti-diabetic potential. We have summarized recent research of natural polysaccharides with hypoglycemic activities, focusing on different pharmacological mechanisms in various cell and animal models. The relationships of structure-hypoglycemic effect are also discussed in detail. This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus, which have been required by clinical studies yet. |
| first_indexed | 2024-03-12T03:16:06Z |
| format | Article |
| id | doaj.art-6e3a96996d7d467fb914c0775c18c75a |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T03:16:06Z |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-6e3a96996d7d467fb914c0775c18c75a2023-09-03T14:10:25ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112619691980Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resourcesXiaolong Ji0Jianhang Guo1Tengzheng Cao2Tingting Zhang3Yanqi Liu4Yizhe Yan5College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China; Henan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou 450001, China; Collaborative Innovation Center of Food Production and Safety, Henan Province, Zhengzhou 450001,ChinaCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China; Henan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou 450001, China; Collaborative Innovation Center of Food Production and Safety, Henan Province, Zhengzhou 450001,China; Correspondence authors at: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China; Henan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou 450001, China; Collaborative Innovation Center of Food Production and Safety, Henan Province, Zhengzhou 450001,China; Food Laboratory of Zhongyuan, Zhengzhou University of Light Industry, Zhengzhou 450001, China; Correspondence authors at: College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaDiabetes mellitus (DM) is a common multifactorial disease, causing various complications, such as chronic metabolism. The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect. However, polysaccharides mainly extracted from natural resources, have advantages of safety, accessibility, and anti-diabetic potential. We have summarized recent research of natural polysaccharides with hypoglycemic activities, focusing on different pharmacological mechanisms in various cell and animal models. The relationships of structure-hypoglycemic effect are also discussed in detail. This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus, which have been required by clinical studies yet.http://www.sciencedirect.com/science/article/pii/S2213453023000691PolysaccharidesHypoglycemic effectMechanismsStructure-activity relationship |
| spellingShingle | Xiaolong Ji Jianhang Guo Tengzheng Cao Tingting Zhang Yanqi Liu Yizhe Yan Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources Food Science and Human Wellness Polysaccharides Hypoglycemic effect Mechanisms Structure-activity relationship |
| title | Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources |
| title_full | Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources |
| title_fullStr | Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources |
| title_full_unstemmed | Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources |
| title_short | Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources |
| title_sort | review on mechanisms and structure activity relationship of hypoglycemic effects of polysaccharides from natural resources |
| topic | Polysaccharides Hypoglycemic effect Mechanisms Structure-activity relationship |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000691 |
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