CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS
In obese patients, the relationship between the content of chemerin in blood plasma and the expression of genes TFAM, Drp1, MFN2, SOD, BAX, responsible for quality control of mitochondria, in insulin-dependent tissues (adipose tissue, liver) was revealed. The tissue-specific features of gene express...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2021-10-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2433 |
| _version_ | 1797197890235400192 |
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| author | M. A. Vulf D. A. Shunkina (Skuratovskaia) V. Hung A. A. Komar P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova |
| author_facet | M. A. Vulf D. A. Shunkina (Skuratovskaia) V. Hung A. A. Komar P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova |
| author_sort | M. A. Vulf |
| collection | DOAJ |
| description | In obese patients, the relationship between the content of chemerin in blood plasma and the expression of genes TFAM, Drp1, MFN2, SOD, BAX, responsible for quality control of mitochondria, in insulin-dependent tissues (adipose tissue, liver) was revealed. The tissue-specific features of gene expression (TFAM, Drp1, MFN2, SOD, BAX), the number of mtDNA copies in the studied depots in obese patients were established. It has been proven that a change (decrease) in the number of mtDNA copies in insulin-dependent tissues can have a protective effect on mitochondria under conditions of increased oxidative stress. It was found that in patients without type 2 diabetes, an increase in chemerin production promotes the activation of the antioxidant system in the visceral adipose tissue but not in the liver. On the contrary, all obese patients with type 2 diabetes showed a decrease (compared with patients without type 2 diabetes) in the plasma level of chemerin. Thus, the low content of chemerin in the blood plasma in patients with type 2 diabetes mediates the formation of mitochondrial dysfunction in insulin-dependent tissues (adipose tissue, liver). |
| first_indexed | 2024-03-08T05:47:46Z |
| format | Article |
| id | doaj.art-6e3c5b1a82214d2f8e68ce273de571ad |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:51:09Z |
| publishDate | 2021-10-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-6e3c5b1a82214d2f8e68ce273de571ad2024-04-22T13:07:47ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2021-10-0123488188610.15789/1563-0625-CAA-22271460CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTSM. A. Vulf0D. A. Shunkina (Skuratovskaia)1V. Hung2A. A. Komar3P. A. Zatolokin4E. V. Kirienkova5N. D. Gazatova6L. S. Litvinova7Immanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityIn obese patients, the relationship between the content of chemerin in blood plasma and the expression of genes TFAM, Drp1, MFN2, SOD, BAX, responsible for quality control of mitochondria, in insulin-dependent tissues (adipose tissue, liver) was revealed. The tissue-specific features of gene expression (TFAM, Drp1, MFN2, SOD, BAX), the number of mtDNA copies in the studied depots in obese patients were established. It has been proven that a change (decrease) in the number of mtDNA copies in insulin-dependent tissues can have a protective effect on mitochondria under conditions of increased oxidative stress. It was found that in patients without type 2 diabetes, an increase in chemerin production promotes the activation of the antioxidant system in the visceral adipose tissue but not in the liver. On the contrary, all obese patients with type 2 diabetes showed a decrease (compared with patients without type 2 diabetes) in the plasma level of chemerin. Thus, the low content of chemerin in the blood plasma in patients with type 2 diabetes mediates the formation of mitochondrial dysfunction in insulin-dependent tissues (adipose tissue, liver).https://www.mimmun.ru/mimmun/article/view/2433obesityt2dmmitochondriachemerinliveradipose tissuemtdna |
| spellingShingle | M. A. Vulf D. A. Shunkina (Skuratovskaia) V. Hung A. A. Komar P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS Медицинская иммунология obesity t2dm mitochondria chemerin liver adipose tissue mtdna |
| title | CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS |
| title_full | CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS |
| title_fullStr | CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS |
| title_full_unstemmed | CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS |
| title_short | CHEMERIN AS A POTENTIAL REGULATOR OF MITOCHONDRIAL QUALITY CONTROL IN OBESE PATIENTS |
| title_sort | chemerin as a potential regulator of mitochondrial quality control in obese patients |
| topic | obesity t2dm mitochondria chemerin liver adipose tissue mtdna |
| url | https://www.mimmun.ru/mimmun/article/view/2433 |
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