Spatial transcriptomics tools allow for regional exploration of heterogeneous muscle pathology in the pre-clinical rabbit model of rotator cuff tear

Spatial transcriptomics tools allow for regional exploration of heterogeneous muscle pathology in the pre-clinical rabbit model of rotator cuff tear

Abstract Background Conditions affecting skeletal muscle, such as chronic rotator cuff tears, low back pain, dystrophies, and many others, often share changes in muscle phenotype: intramuscular adipose and fibrotic tissue increase while contractile tissue is lost. The underlying changes in cell popu...

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Bibliographic Details
Main Authors: Severin Ruoss, Mary C. Esparza, Laura S. Vasquez-Bolanos, Chanond A. Nasamran, Kathleen M. Fisch, Adam J. Engler, Samuel R. Ward
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Spatial transcriptomics
Visium
RNA-sequencing
Rotator cuff
Online Access:https://doi.org/10.1186/s13018-022-03326-8

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