A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli.
Toxin-Antitoxin modules are small operons involved in stress response and persister cell formation that encode a "toxin" and its corresponding neutralizing "antitoxin". Regulation of these modules involves a complex mechanism known as conditional cooperativity, which is supposed...
Main Authors: | Lendert Gelens, Lydia Hill, Alexandra Vandervelde, Jan Danckaert, Remy Loris |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC3757116?pdf=render |
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