Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux

Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux

(Macro)autophagy is a cellular degradation system for unnecessary materials, such as aggregate-prone TDP-43, a central molecule in neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Abemaciclib (Abe) and vacuolin-1 (Vac) treatments are known to...

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Bibliographic Details
Main Authors:	Yoshinori Tanaka, Lina Kozuma, Hirotsugu Hino, Kosuke Takeya, Masumi Eto
Format:	Article
Language:	English
Published:	Elsevier 2024-07-01
Series:	Biochemistry and Biophysics Reports
Subjects:	Abemaciclib Vacuolin-1 Autophagic flux TDP-43 PI(3)P
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580824000694

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