The Roles of Solute Carriers in Auditory Function
Solute carriers (SLCs) are important transmembrane transporters with members organized into 65 families. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. SLCs also play important roles in heari...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.823049/full |
| _version_ | 1818954941478207488 |
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| author | Fuping Qian Xiaoge Jiang Renjie Chai Renjie Chai Renjie Chai Renjie Chai Renjie Chai Dong Liu Dong Liu |
| author_facet | Fuping Qian Xiaoge Jiang Renjie Chai Renjie Chai Renjie Chai Renjie Chai Renjie Chai Dong Liu Dong Liu |
| author_sort | Fuping Qian |
| collection | DOAJ |
| description | Solute carriers (SLCs) are important transmembrane transporters with members organized into 65 families. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. SLCs also play important roles in hearing. It has been found that mutations in some SLC members are associated with hearing loss. In this review, we summarize SLC family genes related with hearing dysfunction to reveal the vital roles of these transporters in auditory function. This summary could help us understand the auditory physiology and the mechanisms of hearing loss and further guide future studies of deafness gene identification. |
| first_indexed | 2024-12-20T10:30:10Z |
| format | Article |
| id | doaj.art-6e454eb0acd2411cb6d70b23cff028e8 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-20T10:30:10Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-6e454eb0acd2411cb6d70b23cff028e82022-12-21T19:43:45ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-01-011310.3389/fgene.2022.823049823049The Roles of Solute Carriers in Auditory FunctionFuping Qian0Xiaoge Jiang1Renjie Chai2Renjie Chai3Renjie Chai4Renjie Chai5Renjie Chai6Dong Liu7Dong Liu8School of Life Sciences, Nantong University, Nantong, ChinaDepartment of Rehabilitation Medicine, The Second People’s Hospital of Nantong, Affiliated Rehabilitation Hospital of Nantong University, Nantong, ChinaState Key Laboratory of Bioelectronics, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaCo-Innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaInstitute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, ChinaBeijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, ChinaDepartment of Otolaryngology Head and Neck Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Life Sciences, Nantong University, Nantong, ChinaCo-Innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaSolute carriers (SLCs) are important transmembrane transporters with members organized into 65 families. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. SLCs also play important roles in hearing. It has been found that mutations in some SLC members are associated with hearing loss. In this review, we summarize SLC family genes related with hearing dysfunction to reveal the vital roles of these transporters in auditory function. This summary could help us understand the auditory physiology and the mechanisms of hearing loss and further guide future studies of deafness gene identification.https://www.frontiersin.org/articles/10.3389/fgene.2022.823049/fullsolute carrierSLCtransporterhereditary hearing lossdeafness gene |
| spellingShingle | Fuping Qian Xiaoge Jiang Renjie Chai Renjie Chai Renjie Chai Renjie Chai Renjie Chai Dong Liu Dong Liu The Roles of Solute Carriers in Auditory Function Frontiers in Genetics solute carrier SLC transporter hereditary hearing loss deafness gene |
| title | The Roles of Solute Carriers in Auditory Function |
| title_full | The Roles of Solute Carriers in Auditory Function |
| title_fullStr | The Roles of Solute Carriers in Auditory Function |
| title_full_unstemmed | The Roles of Solute Carriers in Auditory Function |
| title_short | The Roles of Solute Carriers in Auditory Function |
| title_sort | roles of solute carriers in auditory function |
| topic | solute carrier SLC transporter hereditary hearing loss deafness gene |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.823049/full |
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