Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events

Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-chemical stressors. The action of ROS and RNS, collectively refe...

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Main Authors: Shihori Tanabe, Jason O’Brien, Knut Erik Tollefsen, Youngjun Kim, Vinita Chauhan, Carole Yauk, Elizabeth Huliganga, Ruthann A. Rudel, Jennifer E. Kay, Jessica S. Helm, Danielle Beaton, Julija Filipovska, Iva Sovadinova, Natalia Garcia-Reyero, Angela Mally, Sarah Søs Poulsen, Nathalie Delrue, Ellen Fritsche, Karsta Luettich, Cinzia La Rocca, Hasmik Yepiskoposyan, Jördis Klose, Pernille Høgh Danielsen, Maranda Esterhuizen, Nicklas Raun Jacobsen, Ulla Vogel, Timothy W. Gant, Ian Choi, Rex FitzGerald
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Toxicology
Subjects:
adverse outcome pathway (AOP)
oxidative stress
reactive nitrogen species (RNS)
disease
reactive oxygen species (ROS)
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.887135/full

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