Avapritinib: a new tyrosine kinase inhibitor for treatment of advanced gastrointestinal stromal tumors. The literature review and clinical case

Avapritinib: a new tyrosine kinase inhibitor for treatment of advanced gastrointestinal stromal tumors. The literature review and clinical case

We have three drugs for treatment of gastrointestinal stromal tumors (GIST): imatinib, sunitinib and regorafenib. Avapritinib (Ayvakit, BLU-285) is one more drug that was approved in January 2020. Avapritinib is a new selective tyrosine kinase inhibitor of PDGFRA and KIT mutations. Based on NAVIGATO...

Full description

Bibliographic Details
Main Authors:	Daria A. Filonenko, Bela M. Medvedeva, Andrey A. Meshcheryakov
Format:	Article
Language:	Russian
Published:	IP Habib O.N. 2021-02-01
Series:	Современная онкология
Subjects:	gastrointestinal stromal tumors pdgfra avapritinib blu-285 ayvakit
Online Access:	https://modernonco.orscience.ru/1815-1434/article/viewFile/61163/44252

Similar Items

Targeting kinases with precision
by: Alexandra K. Gardino, et al.
Published: (2018-05-01)

Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor
by: Sebastian Bauer, et al.
Published: (2021-07-01)

Novel approaches to treating advanced systemic mastocytosis
by: Gilreath JA, et al.
Published: (2019-07-01)

An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors
by: Yingchao Sun, et al.
Published: (2022-08-01)

Avapritinib-induced photo-aggravated cutaneous reaction
by: Farinoosh Dadrass, MS, et al.
Published: (2022-03-01)

Abrupt onset of severe parkinsonism in a patient with metastatic gastrointestinal stromal tumor receiving treatment with avapritinib: A case report
by: Claire Drom, et al.
Published: (2023-02-01)

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour
by: Valli PRIYA, et al.
Published: (2020-05-01)

Outstanding Response to Sorafenib in a Patient with Metastatic Gastrointestinal Stromal Tumour
by: Charlotte Brinch, et al.
Published: (2021-11-01)

Primary extra-gastrointestinal stromal tumor of retroperitoneum: Clinicopathologic characteristics and prognosis of six cases
by: Jiaxin Lin, et al.
Published: (2023-02-01)

Long-term response to pimitespib in postoperative recurrent gastrointestinal stromal tumors with PDGFRA D842V mutation: a case report
by: Ryugo Teranishi, et al.
Published: (2023-04-01)

A case of indolent systemic mastocytosis responding to treatment with Avapritinib
by: Terrence Sun, et al.
Published: (2024-02-01)

Gastrointestinal Stromal Tumors of Small Intestine
by: Tanweerul Huda, et al.
Published: (2019-07-01)

The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor
by: Annalisa Astolfi, et al.
Published: (2020-05-01)

Prognostic factors in patients with disseminated gastrointestinal stromal tumors
by: P P Arkhiri, et al.
Published: (2016-06-01)

Identification of New Tumor-Related Gene Mutations in Chinese Gastrointestinal Stromal Tumors
by: Yuyang Feng, et al.
Published: (2021-11-01)

Clinicopathologic characteristics, diagnostic clues, and prognoses of patients with multiple sporadic gastrointestinal stromal tumors: a case series and review of the literature
by: Yan-Ying Shen, et al.
Published: (2020-05-01)

Results on prognostic value of mutations in localized gastrointestinal stromal tumors (GIST): in one single center Valor pronóstico de las mutaciones en tumores estromales gastrointestinales localizados (GIST): resultados de un solo centro
by: Marina Garcés-Albir, et al.
Published: (2012-08-01)

Correlation of KIT and PDGFRA mutation status with clinicopathologic features in primary and recurrent or metastatic gastrointestinal stromal tumors
by: GU Yijin, LI Anqi, DONG Lei, XU Haimin, SHEN Xia, XIE Jialing, YUAN Fei, WANG Chaofu
Published: (2021-06-01)

Palpable purpuric eruption mimicking vasculitis following avapritinib
by: Taha Osman Mohammed, BS, et al.
Published: (2022-04-01)

The Identity of PDGFRA D842V-Mutant Gastrointestinal Stromal Tumors (GIST)
by: Alessandro Rizzo, et al.
Published: (2021-02-01)

Avapritinib treatment of KIT D816V-mutant atypical chronic myeloid leukemia
by: Lyndsey Sandow, et al.
Published: (2023-01-01)

ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation:a case report
by: Jun Fan, et al.
Published: (2020-01-01)

Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth
by: Eva Serrano‐Candelas, et al.
Published: (2018-08-01)

Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors
by: César Serrano, et al.
Published: (2020-02-01)

The importance of molecular biology in development, prognosis, treatment and resistance to targeted therapy in gastrointestinal stromal tumors
by: Alessandro Comandone, et al.
Published: (2011-12-01)

Development and validation of the quantitative determination of avapritinib in rat plasma by a bioanalytical method of UPLC-MS/MS
by: Xuegu Xu, et al.
Published: (2021-06-01)

Current Molecular Profile of Gastrointestinal Stromal Tumors and Systemic Therapeutic Implications
by: Maria Cecilia Mathias-Machado, et al.
Published: (2022-10-01)

Outcomes of Late-Line Systemic Treatment in GIST: Does Sequence Matter?
by: Prapassorn Thirasastr, et al.
Published: (2024-02-01)

Evaluation of Systemic Treatment Options for Gastrointestinal Stromal Tumours
by: Marin Golčić, et al.
Published: (2023-08-01)

Mutational Analysis of <i>c-KIT</i> and <i>PDGFRA</i> in Canine Gastrointestinal Stromal Tumors (GISTs)
by: Maria Morini, et al.
Published: (2022-07-01)

Surgical treatment of the metastatic gastrointestinal stromal tumor after resistance to available tyrosine kinase inhibitors: A case report
by: Haidong Zhang, et al.
Published: (2023-02-01)

Deep Convolutional Neural Networks Detect Tumor Genotype from Pathological Tissue Images in Gastrointestinal Stromal Tumors
by: Cher-Wei Liang, et al.
Published: (2021-11-01)

Haviland's Subterranean Termite, Coptotermes havilandi Holmgren (Insecta: Isoptera: Rhinotermitidae)
by: Rudolf H. Scheffrahn, et al.
Published: (2002-11-01)

Application of Ionophores in Cattle Diets
by: Matt Hersom, et al.
Published: (2012-12-01)

Cost-Effectiveness Analysis of Tyrosine Kinase Inhibitors in Gastrointestinal Stromal Tumor: A Systematic Review
by: Mingyang Feng, et al.
Published: (2022-01-01)

Gastrointestinal stromal tumors (GISTs): role of CD 117 and PDGFRA Golgi-like staining pattern in the recognition of mutational status Tumores del estroma gastrointestinal (GISTs): patrón de tinción tipo Golgi de CD 117 Y PDGFRA en el reconocimiento del estado mutacional
by: Sara Jaramillo, et al.
Published: (2012-03-01)

Üst gastrointestinal sistem kanaması ile başvuran gastrik gastrointestinal stromal tümör olgusu
by: Doğan Nasır BİNİCİ, et al.
Published: (2017-03-01)

Receptor-Tyrosine Kinase Inhibitor Ponatinib Inhibits Meningioma Growth In Vitro and In Vivo
by: Tao Yu, et al.
Published: (2021-11-01)

Outcomes of surgical treatment of advanced gastrointestinal stromal tumors
by: O B Abouhaidar, et al.
Published: (2016-03-01)

Interpreting PPE Statements on Pesticide Labels
by: Olaf N. Nesheim
Published: (2004-03-01)