Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors
The signal transduction system of microorganisms helps them adapt to changes in their complex living environment. Two-component system (TCS) is a representative signal transduction system that plays a crucial role in regulating cellular communication and secondary metabolism. In Gram-negative bacter...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Engineering Microbiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266737032200042X |
| _version_ | 1797788389322260480 |
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| author | Huihui Song Yuying Li Yan Wang |
| author_facet | Huihui Song Yuying Li Yan Wang |
| author_sort | Huihui Song |
| collection | DOAJ |
| description | The signal transduction system of microorganisms helps them adapt to changes in their complex living environment. Two-component system (TCS) is a representative signal transduction system that plays a crucial role in regulating cellular communication and secondary metabolism. In Gram-negative bacteria, an unorthodox TCS consisting of histidine kinase protein GacS (initially called LemA) and response regulatory protein GacA is widespread. It mainly regulates various physiological activities and behaviors of bacteria, such as quorum sensing, secondary metabolism, biofilm formation and motility, through the Gac/Rsm (Regulator of secondary metabolism) signaling cascade pathway. The global regulatory ability of GacS/GacA in cell physiological activities makes it a potential research entry point for developing natural products and addressing antibiotic resistance. In this review, we summarize the progress of research on GacS/GacA from various perspectives, including the reaction mechanism, related regulatory pathways, main functions and GacS/GacA-mediated applications. Hopefully, this review will facilitate further research on GacS/GacA and promote its application in regulating secondary metabolism and as a therapeutic target. |
| first_indexed | 2024-03-13T01:35:53Z |
| format | Article |
| id | doaj.art-6e470b19bd52417fabf980bf943c1801 |
| institution | Directory Open Access Journal |
| issn | 2667-3703 |
| language | English |
| last_indexed | 2024-03-13T01:35:53Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Engineering Microbiology |
| spelling | doaj.art-6e470b19bd52417fabf980bf943c18012023-07-04T05:11:25ZengElsevierEngineering Microbiology2667-37032023-03-0131100051Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviorsHuihui Song0Yuying Li1Yan Wang2College of Marine Life Sciences, Ocean University of China, Qingdao 266003, ChinaCollege of Marine Life Sciences, Ocean University of China, Qingdao 266003, ChinaCollege of Marine Life Sciences, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China; Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao 266003, China; Corresponding author.The signal transduction system of microorganisms helps them adapt to changes in their complex living environment. Two-component system (TCS) is a representative signal transduction system that plays a crucial role in regulating cellular communication and secondary metabolism. In Gram-negative bacteria, an unorthodox TCS consisting of histidine kinase protein GacS (initially called LemA) and response regulatory protein GacA is widespread. It mainly regulates various physiological activities and behaviors of bacteria, such as quorum sensing, secondary metabolism, biofilm formation and motility, through the Gac/Rsm (Regulator of secondary metabolism) signaling cascade pathway. The global regulatory ability of GacS/GacA in cell physiological activities makes it a potential research entry point for developing natural products and addressing antibiotic resistance. In this review, we summarize the progress of research on GacS/GacA from various perspectives, including the reaction mechanism, related regulatory pathways, main functions and GacS/GacA-mediated applications. Hopefully, this review will facilitate further research on GacS/GacA and promote its application in regulating secondary metabolism and as a therapeutic target.http://www.sciencedirect.com/science/article/pii/S266737032200042XGacS/GacATwo-component systemSignaling regulatory networkSecondary metaboliteAntibiotic resistance |
| spellingShingle | Huihui Song Yuying Li Yan Wang Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors Engineering Microbiology GacS/GacA Two-component system Signaling regulatory network Secondary metabolite Antibiotic resistance |
| title | Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors |
| title_full | Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors |
| title_fullStr | Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors |
| title_full_unstemmed | Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors |
| title_short | Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors |
| title_sort | two component system gacs gaca a global response regulator of bacterial physiological behaviors |
| topic | GacS/GacA Two-component system Signaling regulatory network Secondary metabolite Antibiotic resistance |
| url | http://www.sciencedirect.com/science/article/pii/S266737032200042X |
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