Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map
Introduction With the rising resistance to artemisinin-based combination treatments, there is a need to hasten the discovery and development of newer antimalarial agents. Herbal medicines are key for the development of novel drugs. Currently, herbal medicine usage in communities for treatment of mal...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/7/e069771.full |
| _version_ | 1797745405871521792 |
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| author | Nakalembe Loyce Robert Apunyo Alison Annet Kinengyere Moses Ocan Ekwaro A Obuku Kevin Ouma Ojiambo |
| author_facet | Nakalembe Loyce Robert Apunyo Alison Annet Kinengyere Moses Ocan Ekwaro A Obuku Kevin Ouma Ojiambo |
| author_sort | Nakalembe Loyce |
| collection | DOAJ |
| description | Introduction With the rising resistance to artemisinin-based combination treatments, there is a need to hasten the discovery and development of newer antimalarial agents. Herbal medicines are key for the development of novel drugs. Currently, herbal medicine usage in communities for treatment of malaria symptoms is common as an alternative to conventional (modern) antimalarial agents. However, the efficacy and safety of most of the herbal medicines has not yet been established. Therefore, this systematic review and evidence gap map (EGM) is intended to collate and map the available evidence, identify the gaps and synthesise the efficacy of herbal antimalarial medicines used in malaria affected regions globally.Methods and analysis The systematic review and EGM will be done following PRISMA and Campbell Collaboration guidelines respectively. This protocol has been registered in PROSPERO. Data sources will include PubMed, MEDLINE Ovid, EMBASE, Web of Science, Google Scholar and grey literature search. Data extraction will be done in duplicate using a data extraction tool tailored in Microsoft Office excel for herbal antimalarials discovery research questions following the PICOST framework. The Risk of Bias and overall quality of evidence will be assessed using Cochrane risk of bias tool (clinical trials), QUIN tool (in vitro studies), Newcastle-Ottawa tool (observational studies) and SYRCLE’s risk of bias tool for animal studies (in vivo studies). Data analysis will be done using both structured narrative and quantitative synthesis. The primary review outcomes will be clinically important efficacy and adverse drug reactions. Laboratory parameters will include Inhibitory Concentration killing 50% of parasites, IC50; Ring Stage Assay, RSA0–3 hou; Trophozoite Survival Assay, TSA50.Ethics and dissemination The review protocol was approved by the School of Biomedical Science Research Ethics Committee, Makerere University College of Health Sciences (SBS-2022-213).PROSPERO registration number CRD42022367073. |
| first_indexed | 2024-03-12T15:23:46Z |
| format | Article |
| id | doaj.art-6e48575220d44ae9955fe5ea1d692ac8 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-12T15:23:46Z |
| publishDate | 2023-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-6e48575220d44ae9955fe5ea1d692ac82023-08-10T19:05:07ZengBMJ Publishing GroupBMJ Open2044-60552023-07-0113710.1136/bmjopen-2022-069771Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap mapNakalembe Loyce0Robert Apunyo1Alison Annet Kinengyere2Moses Ocan3Ekwaro A Obuku4Kevin Ouma Ojiambo5Africa Centre for Systematic Reviews and Knowledge Translation, College of Health Sciences, Makerere University, Kampala, UgandaAfrica Centre for Systematic Reviews and Knowledge Translation, College of Health Sciences, Makerere University, Kampala, UgandaAfrica Centre for Systematic Reviews and Knowledge Translation, College of Health Sciences, Makerere University, Kampala, UgandaPharmacology & Therapeutics, Makerere University College of Health Sciences, Kampala, UgandaClinical Epidemiology Unit, Department of Medicine, Makerere University, Kampala, UgandaAfrica Centre for Systematic Reviews and Knowledge Translation, College of Health Sciences, Makerere University, Kampala, UgandaIntroduction With the rising resistance to artemisinin-based combination treatments, there is a need to hasten the discovery and development of newer antimalarial agents. Herbal medicines are key for the development of novel drugs. Currently, herbal medicine usage in communities for treatment of malaria symptoms is common as an alternative to conventional (modern) antimalarial agents. However, the efficacy and safety of most of the herbal medicines has not yet been established. Therefore, this systematic review and evidence gap map (EGM) is intended to collate and map the available evidence, identify the gaps and synthesise the efficacy of herbal antimalarial medicines used in malaria affected regions globally.Methods and analysis The systematic review and EGM will be done following PRISMA and Campbell Collaboration guidelines respectively. This protocol has been registered in PROSPERO. Data sources will include PubMed, MEDLINE Ovid, EMBASE, Web of Science, Google Scholar and grey literature search. Data extraction will be done in duplicate using a data extraction tool tailored in Microsoft Office excel for herbal antimalarials discovery research questions following the PICOST framework. The Risk of Bias and overall quality of evidence will be assessed using Cochrane risk of bias tool (clinical trials), QUIN tool (in vitro studies), Newcastle-Ottawa tool (observational studies) and SYRCLE’s risk of bias tool for animal studies (in vivo studies). Data analysis will be done using both structured narrative and quantitative synthesis. The primary review outcomes will be clinically important efficacy and adverse drug reactions. Laboratory parameters will include Inhibitory Concentration killing 50% of parasites, IC50; Ring Stage Assay, RSA0–3 hou; Trophozoite Survival Assay, TSA50.Ethics and dissemination The review protocol was approved by the School of Biomedical Science Research Ethics Committee, Makerere University College of Health Sciences (SBS-2022-213).PROSPERO registration number CRD42022367073.https://bmjopen.bmj.com/content/13/7/e069771.full |
| spellingShingle | Nakalembe Loyce Robert Apunyo Alison Annet Kinengyere Moses Ocan Ekwaro A Obuku Kevin Ouma Ojiambo Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map BMJ Open |
| title | Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map |
| title_full | Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map |
| title_fullStr | Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map |
| title_full_unstemmed | Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map |
| title_short | Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map |
| title_sort | efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally a protocol for systematic review and evidence and gap map |
| url | https://bmjopen.bmj.com/content/13/7/e069771.full |
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