Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis

Abstract Objective This is the first systematic review and meta-analysis on the overall incidence of intraspinal abnormalities in patients with congenital scoliosis (CS) and potential influencing factors. Methods We searched three large electronic databases (PubMed, EMBASE, and Cochrane Library) for...

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Main Authors: Xudong Wang, Yangke Yu, Ningning Yang, Lei Xia
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13018-020-02015-8
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author Xudong Wang
Yangke Yu
Ningning Yang
Lei Xia
author_facet Xudong Wang
Yangke Yu
Ningning Yang
Lei Xia
author_sort Xudong Wang
collection DOAJ
description Abstract Objective This is the first systematic review and meta-analysis on the overall incidence of intraspinal abnormalities in patients with congenital scoliosis (CS) and potential influencing factors. Methods We searched three large electronic databases (PubMed, EMBASE, and Cochrane Library) for potentially relevant studies. The quality of the included studies was assessed independently by two authors using the Methodological Index for Non-Randomized Studies (MINORS) criteria. Data on the number of CS patients, number of CS patients with intraspinal abnormalities, sex of the patients, and CS types were extracted from the included studies. R software was used to pool and analyze all the extracted data. Results This meta-analysis included 10 articles, and 671 of 1863 CS patients undergoing magnetic resonance imaging (MRI) examinations were identified to have intraspinal abnormalities. The overall incidence of intraspinal abnormalities in the patients with CS was 37% (95% CI, 29–45%). Diastematomyelia was the most common intraspinal abnormality and was detected in 45.60% of the patients with intraspinal abnormalities (306/671). The remaining intraspinal abnormalities included syringomyelia (273/671, 40.69%), tethered cord (190/671, 28.32%), low conus (58/671, 8.64%), intraspinal mass (39/671, 5.81%), Chiari malformation (32/671, 4.77%), fatty filum (27/671, 4.02%), spina bifida (occulta excluded) (17/671, 2.53%), tumor (17/671, 2.53%), cyst (12/671, 1.79%), syringomyelus (4/671, 0.60%), dural ectasia (1/671, 0.15%), and undiagnosed cord MRI hyperintensity (1/671, 0.15%). The patient’s sex and CS type were not factors that affected the incidence of intraspinal abnormalities in CS patients (all P > 0.05). Conclusions This meta-analysis revealed that the overall incidence of intraspinal abnormalities detected by MRI in CS patients was 37%. Diastematomyelia was the most common intraspinal abnormality. The patient’s sex and CS type were not factors that affected the incidence of intraspinal abnormalities in CS patients.
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spelling doaj.art-6e48d91ff1454058969aebd3df5b3fa12022-12-22T04:23:19ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-10-011511710.1186/s13018-020-02015-8Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysisXudong Wang0Yangke Yu1Ningning Yang2Lei Xia3Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou UniversityAbstract Objective This is the first systematic review and meta-analysis on the overall incidence of intraspinal abnormalities in patients with congenital scoliosis (CS) and potential influencing factors. Methods We searched three large electronic databases (PubMed, EMBASE, and Cochrane Library) for potentially relevant studies. The quality of the included studies was assessed independently by two authors using the Methodological Index for Non-Randomized Studies (MINORS) criteria. Data on the number of CS patients, number of CS patients with intraspinal abnormalities, sex of the patients, and CS types were extracted from the included studies. R software was used to pool and analyze all the extracted data. Results This meta-analysis included 10 articles, and 671 of 1863 CS patients undergoing magnetic resonance imaging (MRI) examinations were identified to have intraspinal abnormalities. The overall incidence of intraspinal abnormalities in the patients with CS was 37% (95% CI, 29–45%). Diastematomyelia was the most common intraspinal abnormality and was detected in 45.60% of the patients with intraspinal abnormalities (306/671). The remaining intraspinal abnormalities included syringomyelia (273/671, 40.69%), tethered cord (190/671, 28.32%), low conus (58/671, 8.64%), intraspinal mass (39/671, 5.81%), Chiari malformation (32/671, 4.77%), fatty filum (27/671, 4.02%), spina bifida (occulta excluded) (17/671, 2.53%), tumor (17/671, 2.53%), cyst (12/671, 1.79%), syringomyelus (4/671, 0.60%), dural ectasia (1/671, 0.15%), and undiagnosed cord MRI hyperintensity (1/671, 0.15%). The patient’s sex and CS type were not factors that affected the incidence of intraspinal abnormalities in CS patients (all P > 0.05). Conclusions This meta-analysis revealed that the overall incidence of intraspinal abnormalities detected by MRI in CS patients was 37%. Diastematomyelia was the most common intraspinal abnormality. The patient’s sex and CS type were not factors that affected the incidence of intraspinal abnormalities in CS patients.http://link.springer.com/article/10.1186/s13018-020-02015-8Congenital scoliosisIntraspinal abnormalitiesMagnetic resonance imagingMeta-analysis
spellingShingle Xudong Wang
Yangke Yu
Ningning Yang
Lei Xia
Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis
Journal of Orthopaedic Surgery and Research
Congenital scoliosis
Intraspinal abnormalities
Magnetic resonance imaging
Meta-analysis
title Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis
title_full Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis
title_fullStr Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis
title_full_unstemmed Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis
title_short Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis
title_sort incidence of intraspinal abnormalities in congenital scoliosis a systematic review and meta analysis
topic Congenital scoliosis
Intraspinal abnormalities
Magnetic resonance imaging
Meta-analysis
url http://link.springer.com/article/10.1186/s13018-020-02015-8
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AT ningningyang incidenceofintraspinalabnormalitiesincongenitalscoliosisasystematicreviewandmetaanalysis
AT leixia incidenceofintraspinalabnormalitiesincongenitalscoliosisasystematicreviewandmetaanalysis