Anti-Aging Effect of <i>Agrocybe aegerita</i> Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota
Polysaccharides extracted from <i>Agrocybe aegerita</i> (AAPS) have various physiological effects. In this study, we used the naturally aging <i>Drosophila melanogaster</i> and D-galactose-induced aging mice as animal models to study the anti-aging effects of AAPS via the all...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/23/3783 |
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| author | Xiaoyan Liu Linxiu Wu Aijun Tong Hongmin Zhen Dong Han Hongyang Yuan Fannian Li Chengtao Wang Guangsen Fan |
| author_facet | Xiaoyan Liu Linxiu Wu Aijun Tong Hongmin Zhen Dong Han Hongyang Yuan Fannian Li Chengtao Wang Guangsen Fan |
| author_sort | Xiaoyan Liu |
| collection | DOAJ |
| description | Polysaccharides extracted from <i>Agrocybe aegerita</i> (AAPS) have various physiological effects. In this study, we used the naturally aging <i>Drosophila melanogaster</i> and D-galactose-induced aging mice as animal models to study the anti-aging effects of AAPS via the alleviation of oxidative stress and regulation of gut microbiota. Results showed that AAPS could significantly prolong lifespan and alleviate oxidative stress induced by H<sub>2</sub>O<sub>2</sub> of <i>Drosophila melanogaster</i>. In addition, AAPS significantly increased the activities of antioxidant enzymes in <i>Drosophila melanogaster</i> and mice, and reduced the content of MDA. Furthermore, AAPS reshaped the disordered intestinal flora, increased the abundance ratio of <i>Firmicutes</i> to <i>Bacteroidetes</i>, and increased the abundance of beneficial bacteria <i>Lactobacillus</i>. Our results demonstrated that AAPS had good antioxidant and potential anti-aging effects in vivo. |
| first_indexed | 2024-03-09T17:47:29Z |
| format | Article |
| id | doaj.art-6e4b57e21c654c3db92b850419e8b722 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T17:47:29Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-6e4b57e21c654c3db92b850419e8b7222023-11-24T10:58:29ZengMDPI AGFoods2304-81582022-11-011123378310.3390/foods11233783Anti-Aging Effect of <i>Agrocybe aegerita</i> Polysaccharide through Regulation of Oxidative Stress and Gut MicrobiotaXiaoyan Liu0Linxiu Wu1Aijun Tong2Hongmin Zhen3Dong Han4Hongyang Yuan5Fannian Li6Chengtao Wang7Guangsen Fan8Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaEngineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou 350002, ChinaEngineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou 350002, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaPolysaccharides extracted from <i>Agrocybe aegerita</i> (AAPS) have various physiological effects. In this study, we used the naturally aging <i>Drosophila melanogaster</i> and D-galactose-induced aging mice as animal models to study the anti-aging effects of AAPS via the alleviation of oxidative stress and regulation of gut microbiota. Results showed that AAPS could significantly prolong lifespan and alleviate oxidative stress induced by H<sub>2</sub>O<sub>2</sub> of <i>Drosophila melanogaster</i>. In addition, AAPS significantly increased the activities of antioxidant enzymes in <i>Drosophila melanogaster</i> and mice, and reduced the content of MDA. Furthermore, AAPS reshaped the disordered intestinal flora, increased the abundance ratio of <i>Firmicutes</i> to <i>Bacteroidetes</i>, and increased the abundance of beneficial bacteria <i>Lactobacillus</i>. Our results demonstrated that AAPS had good antioxidant and potential anti-aging effects in vivo.https://www.mdpi.com/2304-8158/11/23/3783<i>Agrocybe aegerita</i> polysaccharidesanti-agingantioxidant activitygut microbiota |
| spellingShingle | Xiaoyan Liu Linxiu Wu Aijun Tong Hongmin Zhen Dong Han Hongyang Yuan Fannian Li Chengtao Wang Guangsen Fan Anti-Aging Effect of <i>Agrocybe aegerita</i> Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota Foods <i>Agrocybe aegerita</i> polysaccharides anti-aging antioxidant activity gut microbiota |
| title | Anti-Aging Effect of <i>Agrocybe aegerita</i> Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota |
| title_full | Anti-Aging Effect of <i>Agrocybe aegerita</i> Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota |
| title_fullStr | Anti-Aging Effect of <i>Agrocybe aegerita</i> Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota |
| title_full_unstemmed | Anti-Aging Effect of <i>Agrocybe aegerita</i> Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota |
| title_short | Anti-Aging Effect of <i>Agrocybe aegerita</i> Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota |
| title_sort | anti aging effect of i agrocybe aegerita i polysaccharide through regulation of oxidative stress and gut microbiota |
| topic | <i>Agrocybe aegerita</i> polysaccharides anti-aging antioxidant activity gut microbiota |
| url | https://www.mdpi.com/2304-8158/11/23/3783 |
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