Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclus
The Australian paralysis tick Ixodes holocyclus continues to be a serious threat to companion animals along Australia’s east coast. The tick produces a potent neurotoxin which causes a rapidly ascending flaccid paralysis, which if left untreated, can result in the death of the animal. There is curre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Parasitology and Vector-Borne Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667114X23000110 |
| _version_ | 1797371983497789440 |
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| author | Florian Roeber Chrissie Jackson Michael Chambers Veronica Smith Jane Hume Katrin Blazejak Norbert Mencke |
| author_facet | Florian Roeber Chrissie Jackson Michael Chambers Veronica Smith Jane Hume Katrin Blazejak Norbert Mencke |
| author_sort | Florian Roeber |
| collection | DOAJ |
| description | The Australian paralysis tick Ixodes holocyclus continues to be a serious threat to companion animals along Australia’s east coast. The tick produces a potent neurotoxin which causes a rapidly ascending flaccid paralysis, which if left untreated, can result in the death of the animal. There is currently only a limited number of products registered in Australia for the treatment and control of paralysis ticks in cats. Felpreva® is an effective spot-on combination containing emodepside, praziquantel and tigolaner. To investigate the therapeutic and long-term persistent efficacy of Felpreva® (2.04% w/v emodepside, 8.14% w/v praziquantel and 9.79% w/v tigolaner) against experimental infestation with I. holocyclus in cats, two studies were undertaken. Fifty cats were included in the studies on study Day -17. These cats were immunized against paralysis tick holocyclotoxin prior to the study commencing. Immunity to holocyclotoxin was confirmed with a tick carrying capacity (TCC) test conducted prior to treatment. Cats were treated once on Day 0. Group 1 cats were treated with the placebo formulation and Group 2 cats were treated with Felpreva®. Cats were infested on Days -14 (tick carrying capacity test), 0, 28, 56, 70, 84 and 91 (weeks 4, 8, 10, 12 and 13). Ticks were counted on cats 24 h, 48 h and 72 h post-treatment and infestation, except during the tick carrying capacity test when they were counted approximately 72 h post-infestation only. The 24-h and 48-h assessments were conducted without removing the ticks. The ticks were assessed, removed and discarded at the 72-h assessment time-points. Significant differences in total live tick counts at ∼24 h, ∼48 h and ∼72 h post-infestation were observed between the treatment and control group. Differences were significant (P < 0.05 to < 0.001) in all instances. Treatment efficacies of 98.1–100% were observed ∼72 h post-infestation through to 13 weeks (94 days) post-treatment. These results show that a single application of Felpreva® provides effective treatment and control against induced infestation with paralysis ticks for 13 weeks. |
| first_indexed | 2024-03-08T18:29:44Z |
| format | Article |
| id | doaj.art-6e4c27d6a1fd4c5a81ac71e96dcd5dff |
| institution | Directory Open Access Journal |
| issn | 2667-114X |
| language | English |
| last_indexed | 2024-03-08T18:29:44Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Parasitology and Vector-Borne Diseases |
| spelling | doaj.art-6e4c27d6a1fd4c5a81ac71e96dcd5dff2023-12-30T04:45:15ZengElsevierCurrent Research in Parasitology and Vector-Borne Diseases2667-114X2023-01-014100123Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclusFlorian Roeber0Chrissie Jackson1Michael Chambers2Veronica Smith3Jane Hume4Katrin Blazejak5Norbert Mencke6Invetus Pty Ltd., Wongaburra Research Centre, Casino, NSW, 2470, Australia; Corresponding author.Invetus Pty Ltd., Wongaburra Research Centre, Casino, NSW, 2470, AustraliaInvetus Pty Ltd., Wongaburra Research Centre, Casino, NSW, 2470, AustraliaAnimal Ethics Pty Ltd., 363 Steeles Road, Yarra Glen, VIC, 3775, AustraliaVetoquinol Australia PTY LTD, 485 Kingsford Smith Drive, Hamilton, QLD, 4007, AustraliaVetoquinol S.A., 37 rue de la Victoire, 75009, Paris, FranceVetoquinol S.A., 37 rue de la Victoire, 75009, Paris, FranceThe Australian paralysis tick Ixodes holocyclus continues to be a serious threat to companion animals along Australia’s east coast. The tick produces a potent neurotoxin which causes a rapidly ascending flaccid paralysis, which if left untreated, can result in the death of the animal. There is currently only a limited number of products registered in Australia for the treatment and control of paralysis ticks in cats. Felpreva® is an effective spot-on combination containing emodepside, praziquantel and tigolaner. To investigate the therapeutic and long-term persistent efficacy of Felpreva® (2.04% w/v emodepside, 8.14% w/v praziquantel and 9.79% w/v tigolaner) against experimental infestation with I. holocyclus in cats, two studies were undertaken. Fifty cats were included in the studies on study Day -17. These cats were immunized against paralysis tick holocyclotoxin prior to the study commencing. Immunity to holocyclotoxin was confirmed with a tick carrying capacity (TCC) test conducted prior to treatment. Cats were treated once on Day 0. Group 1 cats were treated with the placebo formulation and Group 2 cats were treated with Felpreva®. Cats were infested on Days -14 (tick carrying capacity test), 0, 28, 56, 70, 84 and 91 (weeks 4, 8, 10, 12 and 13). Ticks were counted on cats 24 h, 48 h and 72 h post-treatment and infestation, except during the tick carrying capacity test when they were counted approximately 72 h post-infestation only. The 24-h and 48-h assessments were conducted without removing the ticks. The ticks were assessed, removed and discarded at the 72-h assessment time-points. Significant differences in total live tick counts at ∼24 h, ∼48 h and ∼72 h post-infestation were observed between the treatment and control group. Differences were significant (P < 0.05 to < 0.001) in all instances. Treatment efficacies of 98.1–100% were observed ∼72 h post-infestation through to 13 weeks (94 days) post-treatment. These results show that a single application of Felpreva® provides effective treatment and control against induced infestation with paralysis ticks for 13 weeks.http://www.sciencedirect.com/science/article/pii/S2667114X23000110TicksTigolanerIxodes holocyclusCompanion animalsCats |
| spellingShingle | Florian Roeber Chrissie Jackson Michael Chambers Veronica Smith Jane Hume Katrin Blazejak Norbert Mencke Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclus Current Research in Parasitology and Vector-Borne Diseases Ticks Tigolaner Ixodes holocyclus Companion animals Cats |
| title | Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclus |
| title_full | Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclus |
| title_fullStr | Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclus |
| title_full_unstemmed | Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclus |
| title_short | Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclus |
| title_sort | efficacy and safety of felpreva r a spot on formulation for cats containing emodepside praziquantel and tigolaner against experimental infestation with the australian paralysis tick ixodes holocyclus |
| topic | Ticks Tigolaner Ixodes holocyclus Companion animals Cats |
| url | http://www.sciencedirect.com/science/article/pii/S2667114X23000110 |
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