Easy and Versatile Technique for the Preparation of Stable and Active Lipase-Based CLEA-like Copolymers by Using Two Homofunctional Cross-Linking Agents: Application to the Preparation of Enantiopure Ibuprofen

Easy and Versatile Technique for the Preparation of Stable and Active Lipase-Based CLEA-like Copolymers by Using Two Homofunctional Cross-Linking Agents: Application to the Preparation of Enantiopure Ibuprofen

An easy and versatile method was designed and applied successfully to obtain access to lipase-based cross-linked-enzyme aggregate-like copolymers (CLEA-LCs) using one-pot, consecutive cross-linking steps using two types of homobifunctional cross-linkers (glutaraldehyde and putrescine), mediated with...

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Bibliographic Details
Main Authors: Oussama Khiari, Nassima Bouzemi, José María Sánchez-Montero, Andrés R. Alcántara
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
CLEA-like copolymers
one-pot immobilization
cross-linkers
pH jump
amine activation
ibuprofen resolution
Online Access:https://www.mdpi.com/1422-0067/24/17/13664

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https://www.mdpi.com/1422-0067/24/17/13664

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