The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains
Abstract Background Port wine stains slowly grow thicker over time, nodules appear on the surface, and the color slowly deepens from pink to purple. Even after laser treatment, some port wine stains will recur and slowly grow, and the erythema appears again. The purpose of this study was to investig...
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-08-01
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| Series: | Maxillofacial Plastic and Reconstructive Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40902-023-00395-5 |
| _version_ | 1797577443301654528 |
|---|---|
| author | Quan-Feng Luo |
| author_facet | Quan-Feng Luo |
| author_sort | Quan-Feng Luo |
| collection | DOAJ |
| description | Abstract Background Port wine stains slowly grow thicker over time, nodules appear on the surface, and the color slowly deepens from pink to purple. Even after laser treatment, some port wine stains will recur and slowly grow, and the erythema appears again. The purpose of this study was to investigate the effectiveness of bleomycin in combination with triamcinolone acetonide in the treatment of inhibiting the proliferation and recurrence of port wine stains. Results Histopathological change: Before treatment, dense capillaries were distributed within the lesion, and blood fills the lumen. Lack of normal skin structure: After bleomycin and triamcinolone acetonide injection, the number of capillaries was significantly reduced, and fibrosis occurred in tissues. Changes in facial morphology: After treatment, the port wine stains became thinner, the asymmetry of the face was effectively improved, and the appearance have been significantly improved. After 5 years of follow-up, there were no recurrent cases. Conclusion Bleomycin and triamcinolone acetonide injection can effectively inhibit the proliferation of port wine stains and prevent port wine stains from recurring after treatment. |
| first_indexed | 2024-03-10T22:09:23Z |
| format | Article |
| id | doaj.art-6e4f608b608d4f649ff8e56c716a6a31 |
| institution | Directory Open Access Journal |
| issn | 2288-8586 |
| language | English |
| last_indexed | 2024-03-10T22:09:23Z |
| publishDate | 2023-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Maxillofacial Plastic and Reconstructive Surgery |
| spelling | doaj.art-6e4f608b608d4f649ff8e56c716a6a312023-11-19T12:41:32ZengSpringerOpenMaxillofacial Plastic and Reconstructive Surgery2288-85862023-08-014511710.1186/s40902-023-00395-5The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stainsQuan-Feng Luo0Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of StomatologyAbstract Background Port wine stains slowly grow thicker over time, nodules appear on the surface, and the color slowly deepens from pink to purple. Even after laser treatment, some port wine stains will recur and slowly grow, and the erythema appears again. The purpose of this study was to investigate the effectiveness of bleomycin in combination with triamcinolone acetonide in the treatment of inhibiting the proliferation and recurrence of port wine stains. Results Histopathological change: Before treatment, dense capillaries were distributed within the lesion, and blood fills the lumen. Lack of normal skin structure: After bleomycin and triamcinolone acetonide injection, the number of capillaries was significantly reduced, and fibrosis occurred in tissues. Changes in facial morphology: After treatment, the port wine stains became thinner, the asymmetry of the face was effectively improved, and the appearance have been significantly improved. After 5 years of follow-up, there were no recurrent cases. Conclusion Bleomycin and triamcinolone acetonide injection can effectively inhibit the proliferation of port wine stains and prevent port wine stains from recurring after treatment.https://doi.org/10.1186/s40902-023-00395-5Port wine stainsBleomycinTriamcinolone acetonideHypertrophyRecurrence |
| spellingShingle | Quan-Feng Luo The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains Maxillofacial Plastic and Reconstructive Surgery Port wine stains Bleomycin Triamcinolone acetonide Hypertrophy Recurrence |
| title | The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains |
| title_full | The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains |
| title_fullStr | The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains |
| title_full_unstemmed | The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains |
| title_short | The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains |
| title_sort | combined application of bleomycin with triamcinolone acetonide in port wine stains inhibiting proliferation and recurrence of port wine stains |
| topic | Port wine stains Bleomycin Triamcinolone acetonide Hypertrophy Recurrence |
| url | https://doi.org/10.1186/s40902-023-00395-5 |
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