Prognostic <sup>18</sup>F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian Cancer
High-grade serous ovarian cancer (HGSOC) is an aggressive disease with different clinical outcomes and poor prognosis. This could be due to tumor heterogeneity. The 18F-FDG PET radiomic parameters permit addressing tumor heterogeneity. Nevertheless, this has been not well studied in ovarian cancer....
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/22/3394 |
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| author | Daniela Travaglio Morales Carlos Huerga Cabrerizo Itsaso Losantos García Mónica Coronado Poggio José Manuel Cordero García Elena López Llobet Domenico Monachello Araujo Sebastián Rizkallal Monzón Luis Domínguez Gadea |
| author_facet | Daniela Travaglio Morales Carlos Huerga Cabrerizo Itsaso Losantos García Mónica Coronado Poggio José Manuel Cordero García Elena López Llobet Domenico Monachello Araujo Sebastián Rizkallal Monzón Luis Domínguez Gadea |
| author_sort | Daniela Travaglio Morales |
| collection | DOAJ |
| description | High-grade serous ovarian cancer (HGSOC) is an aggressive disease with different clinical outcomes and poor prognosis. This could be due to tumor heterogeneity. The 18F-FDG PET radiomic parameters permit addressing tumor heterogeneity. Nevertheless, this has been not well studied in ovarian cancer. The aim of our work was to assess the prognostic value of pretreatment 18F-FDG PET radiomic features in patients with HGSOC. A review of 36 patients diagnosed with advanced HGSOC between 2016 and 2020 in our center was performed. Radiomic features were obtained from pretreatment <sup>18</sup>F-FDGPET. Disease-free survival (DFS) and overall survival (OS) were calculated. Optimal cutoff values with receiver operating characteristic curve/median values were used. A correlation between radiomic features and DFS/OS was made. The mean DFS was 19.6 months and OS was 37.1 months. Total Lesion Glycolysis (TLG), GLSZM_ Zone Size Non-Uniformity (GLSZM_ZSNU), and GLRLM_Run Length Non-Uniformity (GLRLM_RLNU) were significantly associated with DFS. The survival-curves analysis showed a significant difference of DSF in patients with GLRLM_RLNU > 7388.3 versus patients with lower values (19.7 months vs. 31.7 months, <i>p</i> = 0.035), maintaining signification in the multivariate analysis (<i>p =</i> 0.048). Moreover, Intensity-based Kurtosis was associated with OS (<i>p</i> = 0.027). Pretreatment <sup>18</sup>F-FDG PET radiomic features GLRLM_RLNU, GLSZM_ZSNU, and Kurtosis may have prognostic value in patients with advanced HGSOC. |
| first_indexed | 2024-03-09T16:53:48Z |
| format | Article |
| id | doaj.art-6e502d5d74a64490b4126c7a65ac5caf |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T16:53:48Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6e502d5d74a64490b4126c7a65ac5caf2023-11-24T14:37:25ZengMDPI AGDiagnostics2075-44182023-11-011322339410.3390/diagnostics13223394Prognostic <sup>18</sup>F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian CancerDaniela Travaglio Morales0Carlos Huerga Cabrerizo1Itsaso Losantos García2Mónica Coronado Poggio3José Manuel Cordero García4Elena López Llobet5Domenico Monachello Araujo6Sebastián Rizkallal Monzón7Luis Domínguez Gadea8Nuclear Medicine Department, La Paz University Hospital, 28046 Madrid, SpainDepartment of Medical Physics and Radiation Protection, La Paz University Hospital, 28046 Madrid, SpainBiostatistics Department, La Paz University Hospital, 28046 Madrid, SpainNuclear Medicine Department, La Paz University Hospital, 28046 Madrid, SpainNuclear Medicine Department, La Paz University Hospital, 28046 Madrid, SpainNuclear Medicine Department, La Paz University Hospital, 28046 Madrid, SpainNuclear Medicine Department, La Paz University Hospital, 28046 Madrid, SpainNuclear Medicine Department, La Paz University Hospital, 28046 Madrid, SpainNuclear Medicine Department, La Paz University Hospital, 28046 Madrid, SpainHigh-grade serous ovarian cancer (HGSOC) is an aggressive disease with different clinical outcomes and poor prognosis. This could be due to tumor heterogeneity. The 18F-FDG PET radiomic parameters permit addressing tumor heterogeneity. Nevertheless, this has been not well studied in ovarian cancer. The aim of our work was to assess the prognostic value of pretreatment 18F-FDG PET radiomic features in patients with HGSOC. A review of 36 patients diagnosed with advanced HGSOC between 2016 and 2020 in our center was performed. Radiomic features were obtained from pretreatment <sup>18</sup>F-FDGPET. Disease-free survival (DFS) and overall survival (OS) were calculated. Optimal cutoff values with receiver operating characteristic curve/median values were used. A correlation between radiomic features and DFS/OS was made. The mean DFS was 19.6 months and OS was 37.1 months. Total Lesion Glycolysis (TLG), GLSZM_ Zone Size Non-Uniformity (GLSZM_ZSNU), and GLRLM_Run Length Non-Uniformity (GLRLM_RLNU) were significantly associated with DFS. The survival-curves analysis showed a significant difference of DSF in patients with GLRLM_RLNU > 7388.3 versus patients with lower values (19.7 months vs. 31.7 months, <i>p</i> = 0.035), maintaining signification in the multivariate analysis (<i>p =</i> 0.048). Moreover, Intensity-based Kurtosis was associated with OS (<i>p</i> = 0.027). Pretreatment <sup>18</sup>F-FDG PET radiomic features GLRLM_RLNU, GLSZM_ZSNU, and Kurtosis may have prognostic value in patients with advanced HGSOC.https://www.mdpi.com/2075-4418/13/22/3394radiomicsPETtexture featuresheterogeneityovarian cancerprognosis |
| spellingShingle | Daniela Travaglio Morales Carlos Huerga Cabrerizo Itsaso Losantos García Mónica Coronado Poggio José Manuel Cordero García Elena López Llobet Domenico Monachello Araujo Sebastián Rizkallal Monzón Luis Domínguez Gadea Prognostic <sup>18</sup>F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian Cancer Diagnostics radiomics PET texture features heterogeneity ovarian cancer prognosis |
| title | Prognostic <sup>18</sup>F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian Cancer |
| title_full | Prognostic <sup>18</sup>F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian Cancer |
| title_fullStr | Prognostic <sup>18</sup>F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian Cancer |
| title_full_unstemmed | Prognostic <sup>18</sup>F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian Cancer |
| title_short | Prognostic <sup>18</sup>F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian Cancer |
| title_sort | prognostic sup 18 sup f fdg radiomic features in advanced high grade serous ovarian cancer |
| topic | radiomics PET texture features heterogeneity ovarian cancer prognosis |
| url | https://www.mdpi.com/2075-4418/13/22/3394 |
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