Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis
Abstract Reduced glutathione (GSH) is a crucial antioxidant with recognized roles in malaria pathogenesis and host response. Despite its importance, reports on the association of GSH with malaria are inconsistent. Therefore, this systematic review and meta-analysis investigated the differences in GS...
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| Format: | Article |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-43583-z |
| _version_ | 1797576702561353728 |
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| author | Manas Kotepui Kwuntida Kotepui Aongart Mahittikorn Hideyuki J. Majima Jitbanjong Tangpong Hsiu-Chuan Yen |
| author_facet | Manas Kotepui Kwuntida Kotepui Aongart Mahittikorn Hideyuki J. Majima Jitbanjong Tangpong Hsiu-Chuan Yen |
| author_sort | Manas Kotepui |
| collection | DOAJ |
| description | Abstract Reduced glutathione (GSH) is a crucial antioxidant with recognized roles in malaria pathogenesis and host response. Despite its importance, reports on the association of GSH with malaria are inconsistent. Therefore, this systematic review and meta-analysis investigated the differences in GSH levels in relation to Plasmodium infection. A comprehensive literature search of six electronic databases (Embase, MEDLINE, Ovid, PubMed, Scopus, and ProQuest) was conducted. Of the 2158 initially identified records, 18 met the eligibility criteria. The majority of studies reported a significant decrease in GSH levels in malaria patients compared with uninfected controls, and this was confirmed by meta-analysis (P < 0.01, Hedges g: − 1.47, 95% confidence interval [CI] − 2.48 to − 0.46, I 2 : 99.12%, 17 studies). Additionally, there was no significant difference in GSH levels between Plasmodium falciparum malaria and P. vivax malaria (P = 0.80, Hedges g: 0.11, 95% CI − 0.76 to 0.98, I 2 : 93.23%, three studies). Similarly, no significant variation was observed between symptomatic and asymptomatic malaria cases (P = 0.78, Hedges g: 0.06, 95% CI − 0.34 to 0.46, I 2 : 48.07%, two studies). In conclusion, although GSH levels appear to be generally lower in malaria patients, further detailed studies are necessary to fully elucidate this complex relationship. |
| first_indexed | 2024-03-10T21:57:29Z |
| format | Article |
| id | doaj.art-6e540c2e45d24a43bfd5a1d2edbb8cd8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:57:29Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6e540c2e45d24a43bfd5a1d2edbb8cd82023-11-19T13:05:04ZengNature PortfolioScientific Reports2045-23222023-09-0113111310.1038/s41598-023-43583-zAssociation of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysisManas Kotepui0Kwuntida Kotepui1Aongart Mahittikorn2Hideyuki J. Majima3Jitbanjong Tangpong4Hsiu-Chuan Yen5Medical Technology, School of Allied Health Sciences, Walailak UniversityMedical Technology, School of Allied Health Sciences, Walailak UniversityDepartment of Protozoology, Faculty of Tropical Medicine, Mahidol UniversityMedical Technology, School of Allied Health Sciences, Walailak UniversityMedical Technology, School of Allied Health Sciences, Walailak UniversityDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung UniversityAbstract Reduced glutathione (GSH) is a crucial antioxidant with recognized roles in malaria pathogenesis and host response. Despite its importance, reports on the association of GSH with malaria are inconsistent. Therefore, this systematic review and meta-analysis investigated the differences in GSH levels in relation to Plasmodium infection. A comprehensive literature search of six electronic databases (Embase, MEDLINE, Ovid, PubMed, Scopus, and ProQuest) was conducted. Of the 2158 initially identified records, 18 met the eligibility criteria. The majority of studies reported a significant decrease in GSH levels in malaria patients compared with uninfected controls, and this was confirmed by meta-analysis (P < 0.01, Hedges g: − 1.47, 95% confidence interval [CI] − 2.48 to − 0.46, I 2 : 99.12%, 17 studies). Additionally, there was no significant difference in GSH levels between Plasmodium falciparum malaria and P. vivax malaria (P = 0.80, Hedges g: 0.11, 95% CI − 0.76 to 0.98, I 2 : 93.23%, three studies). Similarly, no significant variation was observed between symptomatic and asymptomatic malaria cases (P = 0.78, Hedges g: 0.06, 95% CI − 0.34 to 0.46, I 2 : 48.07%, two studies). In conclusion, although GSH levels appear to be generally lower in malaria patients, further detailed studies are necessary to fully elucidate this complex relationship.https://doi.org/10.1038/s41598-023-43583-z |
| spellingShingle | Manas Kotepui Kwuntida Kotepui Aongart Mahittikorn Hideyuki J. Majima Jitbanjong Tangpong Hsiu-Chuan Yen Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis Scientific Reports |
| title | Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis |
| title_full | Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis |
| title_fullStr | Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis |
| title_full_unstemmed | Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis |
| title_short | Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis |
| title_sort | association of reduced glutathione levels with plasmodium falciparum and plasmodium vivax malaria a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41598-023-43583-z |
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