Exploring Parametric and Mechanistic Differences between Expi293F<sup>TM</sup> and ExpiCHO-S<sup>TM</sup> Cells for Transient Antibody Production Optimization

Exploring Parametric and Mechanistic Differences between Expi293F<sup>TM</sup> and ExpiCHO-S<sup>TM</sup> Cells for Transient Antibody Production Optimization

Rapidly producing drug-like antibody therapeutics for lead molecule discovery and candidate optimization is typically accomplished by large-scale transient gene expression technologies (TGE) with cultivated mammalian cells. The TGE methodologies have been extensively developed over the past three de...

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Bibliographic Details
Main Authors: Jing Zhou, Guoying Grace Yan, David Cluckey, Caryl Meade, Margaret Ruth, Rhady Sorm, Amy S. Tam, Sean Lim, Constantine Petridis, Laura Lin, Aaron M. D’Antona, Xiaotian Zhong
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Antibodies
Subjects:
antibody production
transient gene expression
HEK cells
CHO cells
Kappa and lambda light chain
transfection reagents
Online Access:https://www.mdpi.com/2073-4468/12/3/53

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