Axonal excitability and conduction alterations caused by levobupivacaine in rat
In this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action poten...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-09-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2017-0025 |
| _version_ | 1818736764538322944 |
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| author | Tuncer Seçkin Tuncer Peker Tülay Burat İlksen Kiziltan Erhan İlhan Barkin Dalkiliç Nizamettin |
| author_facet | Tuncer Seçkin Tuncer Peker Tülay Burat İlksen Kiziltan Erhan İlhan Barkin Dalkiliç Nizamettin |
| author_sort | Tuncer Seçkin |
| collection | DOAJ |
| description | In this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action potential (CNAP) recordings were performed using the suction method over sciatic nerves of Wistar rats before and after administration of 0.05 % (1.7 mmol L−1) levobupivacaine. Levobupivacaine caused complete CNAP area and amplitude depression by blocking conduction in a time-dependent manner. |
| first_indexed | 2024-12-18T00:42:20Z |
| format | Article |
| id | doaj.art-6e55234f2d794971b6d38dcc60721d95 |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-12-18T00:42:20Z |
| publishDate | 2017-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-6e55234f2d794971b6d38dcc60721d952022-12-21T21:26:52ZengSciendoActa Pharmaceutica1846-95582017-09-0167329330710.1515/acph-2017-0025acph-2017-0025Axonal excitability and conduction alterations caused by levobupivacaine in ratTuncer Seçkin0Tuncer Peker Tülay1Burat İlksen2Kiziltan Erhan3İlhan Barkin4Dalkiliç Nizamettin5N.E. University, Meram Faculty of Medicine, Biophysics Department, Konya, TurkeyAnkara University, Faculty of Medicine, Anesthesiology Department, Ankara, TurkeyN.E. University, Meram Faculty of Medicine, Biophysics Department, Konya, TurkeyBaşkent University, Faculty of Medicine, Physiology Department, Ankara, TurkeyN.E. University, Meram Faculty of Medicine, Biophysics Department, Konya, TurkeyN.E. University, Meram Faculty of Medicine, Biophysics Department, Konya, TurkeyIn this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action potential (CNAP) recordings were performed using the suction method over sciatic nerves of Wistar rats before and after administration of 0.05 % (1.7 mmol L−1) levobupivacaine. Levobupivacaine caused complete CNAP area and amplitude depression by blocking conduction in a time-dependent manner.https://doi.org/10.1515/acph-2017-0025levobupivacainenerve conductionexcitabilitythreshold electrotonus |
| spellingShingle | Tuncer Seçkin Tuncer Peker Tülay Burat İlksen Kiziltan Erhan İlhan Barkin Dalkiliç Nizamettin Axonal excitability and conduction alterations caused by levobupivacaine in rat Acta Pharmaceutica levobupivacaine nerve conduction excitability threshold electrotonus |
| title | Axonal excitability and conduction alterations caused by levobupivacaine in rat |
| title_full | Axonal excitability and conduction alterations caused by levobupivacaine in rat |
| title_fullStr | Axonal excitability and conduction alterations caused by levobupivacaine in rat |
| title_full_unstemmed | Axonal excitability and conduction alterations caused by levobupivacaine in rat |
| title_short | Axonal excitability and conduction alterations caused by levobupivacaine in rat |
| title_sort | axonal excitability and conduction alterations caused by levobupivacaine in rat |
| topic | levobupivacaine nerve conduction excitability threshold electrotonus |
| url | https://doi.org/10.1515/acph-2017-0025 |
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