Association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy Chinese adults
PurposeThis study investigated the association of retinal fractal dimension (FD) and blood vessel tortuosity (BVT) with renal function [assessed by estimated glomerular filtrate rate (eGFR)] in healthy Chinese adults using swept-source optical coherence tomographic angiography (SS-OCTA).Materials an...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.925756/full |
| _version_ | 1817990909041573888 |
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| author | Linbin Wu Xia Gong Wei Wang Lei Zhang Jiachen Zhou Xi Ming Meng Yuan Wenyong Huang Lanhua Wang |
| author_facet | Linbin Wu Xia Gong Wei Wang Lei Zhang Jiachen Zhou Xi Ming Meng Yuan Wenyong Huang Lanhua Wang |
| author_sort | Linbin Wu |
| collection | DOAJ |
| description | PurposeThis study investigated the association of retinal fractal dimension (FD) and blood vessel tortuosity (BVT) with renal function [assessed by estimated glomerular filtrate rate (eGFR)] in healthy Chinese adults using swept-source optical coherence tomographic angiography (SS-OCTA).Materials and methodsThis cross-sectional study was conducted among ocular treatment–naïve healthy participants from Guangzhou, China. FD and BVT in the superficial capillary plexus and deep capillary plexus were measured by SS-OCTA with a 3 × 3 macula model. eGFR was calculated using the Xiangya equation, and impaired renal function (IRF) was defined as eGFR = 90 mL/min/1.73 m2. Linear regression was performed to evaluate the relationships between SS-OCTA metrics and renal function.ResultsA total of 729 participants with a mean age of 57.6 ± 9.1 years were included in the final analysis. Compared to participants with normal renal function, those with IRF had lower FD both in the superficial capillary plexus (1.658 ± 0.029 vs. 1.666 ± 0.024, p = 0.001) and deep capillary plexus (1.741 ± 0.016 vs. 1.746 ± 0.016, p = 0.0003), while the deep BVT was larger in participants with IRF than those with normal renal function (1.007 ± 0.002 vs. 1.006 ± 0.002, p = 0.028). The superficial FD was linearly and positively associated with eGFR after adjusting for confounders (β = 0.2257; 95% CI 0.0829–0.3685; p = 0.002), while BVT was not associated with eGFR (all p ≥ 0.05).ConclusionThe patients with IRF had lower FD and larger BVT than those with normal renal function. The superficial FD decreased linearly with renal function deterioration. Our study suggests that the retinal microvasculature can represent a useful indicator of subclinical renal microvascular abnormalities and serve as a useful non-invasive assessment to predict and monitor the progression of renal function. |
| first_indexed | 2024-04-14T01:06:14Z |
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| id | doaj.art-6e5979ce19984d0797e28aa377a12ec9 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-14T01:06:14Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-6e5979ce19984d0797e28aa377a12ec92022-12-22T02:21:14ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-09-01910.3389/fmed.2022.925756925756Association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy Chinese adultsLinbin Wu0Xia Gong1Wei Wang2Lei Zhang3Jiachen Zhou4Xi Ming5Meng Yuan6Wenyong Huang7Lanhua Wang8The First People’s Hospital of Zhaoqing, Zhaoqing, ChinaZhongshan Ophthalmic Center, Guangdong Provincial Clinical Research Center for Ocular Diseases, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou, ChinaZhongshan Ophthalmic Center, Guangdong Provincial Clinical Research Center for Ocular Diseases, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou, ChinaThe First People’s Hospital of Zhaoqing, Zhaoqing, ChinaThe First People’s Hospital of Zhaoqing, Zhaoqing, ChinaThe First People’s Hospital of Zhaoqing, Zhaoqing, ChinaZhongshan Ophthalmic Center, Guangdong Provincial Clinical Research Center for Ocular Diseases, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou, ChinaZhongshan Ophthalmic Center, Guangdong Provincial Clinical Research Center for Ocular Diseases, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou, ChinaZhongshan Ophthalmic Center, Guangdong Provincial Clinical Research Center for Ocular Diseases, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou, ChinaPurposeThis study investigated the association of retinal fractal dimension (FD) and blood vessel tortuosity (BVT) with renal function [assessed by estimated glomerular filtrate rate (eGFR)] in healthy Chinese adults using swept-source optical coherence tomographic angiography (SS-OCTA).Materials and methodsThis cross-sectional study was conducted among ocular treatment–naïve healthy participants from Guangzhou, China. FD and BVT in the superficial capillary plexus and deep capillary plexus were measured by SS-OCTA with a 3 × 3 macula model. eGFR was calculated using the Xiangya equation, and impaired renal function (IRF) was defined as eGFR = 90 mL/min/1.73 m2. Linear regression was performed to evaluate the relationships between SS-OCTA metrics and renal function.ResultsA total of 729 participants with a mean age of 57.6 ± 9.1 years were included in the final analysis. Compared to participants with normal renal function, those with IRF had lower FD both in the superficial capillary plexus (1.658 ± 0.029 vs. 1.666 ± 0.024, p = 0.001) and deep capillary plexus (1.741 ± 0.016 vs. 1.746 ± 0.016, p = 0.0003), while the deep BVT was larger in participants with IRF than those with normal renal function (1.007 ± 0.002 vs. 1.006 ± 0.002, p = 0.028). The superficial FD was linearly and positively associated with eGFR after adjusting for confounders (β = 0.2257; 95% CI 0.0829–0.3685; p = 0.002), while BVT was not associated with eGFR (all p ≥ 0.05).ConclusionThe patients with IRF had lower FD and larger BVT than those with normal renal function. The superficial FD decreased linearly with renal function deterioration. Our study suggests that the retinal microvasculature can represent a useful indicator of subclinical renal microvascular abnormalities and serve as a useful non-invasive assessment to predict and monitor the progression of renal function.https://www.frontiersin.org/articles/10.3389/fmed.2022.925756/fullOCTArenal functioneGFRfractal dimensionblood vessel tortuosity |
| spellingShingle | Linbin Wu Xia Gong Wei Wang Lei Zhang Jiachen Zhou Xi Ming Meng Yuan Wenyong Huang Lanhua Wang Association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy Chinese adults Frontiers in Medicine OCTA renal function eGFR fractal dimension blood vessel tortuosity |
| title | Association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy Chinese adults |
| title_full | Association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy Chinese adults |
| title_fullStr | Association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy Chinese adults |
| title_full_unstemmed | Association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy Chinese adults |
| title_short | Association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy Chinese adults |
| title_sort | association of retinal fractal dimension and vessel tortuosity with impaired renal function among healthy chinese adults |
| topic | OCTA renal function eGFR fractal dimension blood vessel tortuosity |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.925756/full |
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