Computational Studies on Selected Macrolides Active against <i>Escherichia coli</i> Combined with the NMR Study of Tylosin A in Deuterated Chloroform

Computational Studies on Selected Macrolides Active against <i>Escherichia coli</i> Combined with the NMR Study of Tylosin A in Deuterated Chloroform

Although many antibiotics are active against Gram-positive bacteria, fewer also show activity against Gram-negative bacteria. Here, we present a combination of in silico (electron ion-interaction potential, molecular docking, ADMET), NMR, and microbiological investigations of selected macrolides (14...

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Bibliographic Details
Main Authors: Biljana Arsic, Jill Barber, Ana Cikos, Manikandan Kadirvel, Emilija Kostic, Andrew J. McBain, Jelena Milicevic, Angela Oates, Andrew Regan
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
macrolides
bacteria
2D ROESY NMR
Online Access:https://www.mdpi.com/1420-3049/27/21/7280

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