Impact of leptin or melatonin on Sema4D overexpression-related bone metabolism

Impact of leptin or melatonin on Sema4D overexpression-related bone metabolism

Abstract Purpose The current study aims to investigate the regulatory impact of leptin or melatonin on bone metabolism as well as the underlying mechanism in conjunction with Sema4D (monoclonal antibody to semaphorin 4D). Methods Rats were used to create the osteoporosis model utilizing the OVX (OVa...

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Bibliographic Details
Main Authors: Zhenen Lin, Shengren Xiong, Yu Lin, Zhaohui Li, Dan Xie, Xuchao Lin, Xuesheng Chen, Xueyi Lin
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Sema4d
Leptin
Melatonin
Osteoporosis
Bone metabolism
Online Access:https://doi.org/10.1186/s13018-023-03740-6

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