Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis
Abstract Objectives Recurrent Aphthous Stomatitis (RAS) known as recurrent aphthous ulcer is a common and painful ulcerations in oral cavity. It has been suggested that hematological parameters seems to be considered as an etiologic factor. So, this meta-analysis and systematic review was aimed to e...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-024-04072-5 |
| _version_ | 1797258944671907840 |
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| author | Tahoora Mousavi Hossein Jalali Mahmood Moosazadeh |
| author_facet | Tahoora Mousavi Hossein Jalali Mahmood Moosazadeh |
| author_sort | Tahoora Mousavi |
| collection | DOAJ |
| description | Abstract Objectives Recurrent Aphthous Stomatitis (RAS) known as recurrent aphthous ulcer is a common and painful ulcerations in oral cavity. It has been suggested that hematological parameters seems to be considered as an etiologic factor. So, this meta-analysis and systematic review was aimed to examine the relationship between RAS and hematological parameters. Methods Relevant studies were found using online international databases including Scopus, Science direct, Web of science (ISI), PubMed, and Google Scholar search engine between 2000 and October 2023. The quality of all papers was determined by NOS checklist. Heterogeneity between the results of primary studies was evaluated with I-square index and publication bias was performed by Egger’s test and funnel plots. Also, sensitivity analysis was done to check the effect of each of the primary studies on the overall estimate. Also, the statistical analyses were done using Stata software Ver. 11. Results By combining the results of primary studies, the standardized mean difference (SMD) of vitamin B12, ferritin, folic acid, hemoglobin, iron and zinc indices with a 95% confidence interval (CI) between the case (patients with RAS) and control (Healthy) groups were estimated -0.52(-0.89, -0.14), -0.20(-0.51, 0.11), -0.42(-0.95, 0.11), -0.58(-0.90, -0.27), 0.01(-0.12, 0.15), -0.33(-0.81, 0.14) respectively. The patients with vitamin B12, ferritin, folic acid, and iron deficiencies and reduced hemoglobin (Hb) level reported 2.93(2.28, 3.78), 2.50(1.48, 4.22), 1.51(0.53, 4.29), 1.46(0.70, 3.03), and 2.14(1.38, 3.32), times more susceptible to develop RAS than healthy individuals. Conclusion The results of the meta-analysis indicated that the SMD of vitamin B12 serum and Hb levels in the case group was 52%. Our result have also showed that the odds ratio of vitamin B12, ferritin deficiencies, and decreased Hb level in case group was 2.93, 2.50, and 2.14 times more than healthy group. |
| first_indexed | 2024-04-24T23:01:35Z |
| format | Article |
| id | doaj.art-6e5d70935dd74dcf81ad1f9b0588d4d8 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-24T23:01:35Z |
| publishDate | 2024-03-01 |
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| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-6e5d70935dd74dcf81ad1f9b0588d4d82024-03-17T12:40:37ZengBMCBMC Oral Health1472-68312024-03-0124112610.1186/s12903-024-04072-5Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysisTahoora Mousavi0Hossein Jalali1Mahmood Moosazadeh2Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical SciencesThalassemia Research Center, Mazandaran University of Medical SciencesEpidemiology, Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical SciencesAbstract Objectives Recurrent Aphthous Stomatitis (RAS) known as recurrent aphthous ulcer is a common and painful ulcerations in oral cavity. It has been suggested that hematological parameters seems to be considered as an etiologic factor. So, this meta-analysis and systematic review was aimed to examine the relationship between RAS and hematological parameters. Methods Relevant studies were found using online international databases including Scopus, Science direct, Web of science (ISI), PubMed, and Google Scholar search engine between 2000 and October 2023. The quality of all papers was determined by NOS checklist. Heterogeneity between the results of primary studies was evaluated with I-square index and publication bias was performed by Egger’s test and funnel plots. Also, sensitivity analysis was done to check the effect of each of the primary studies on the overall estimate. Also, the statistical analyses were done using Stata software Ver. 11. Results By combining the results of primary studies, the standardized mean difference (SMD) of vitamin B12, ferritin, folic acid, hemoglobin, iron and zinc indices with a 95% confidence interval (CI) between the case (patients with RAS) and control (Healthy) groups were estimated -0.52(-0.89, -0.14), -0.20(-0.51, 0.11), -0.42(-0.95, 0.11), -0.58(-0.90, -0.27), 0.01(-0.12, 0.15), -0.33(-0.81, 0.14) respectively. The patients with vitamin B12, ferritin, folic acid, and iron deficiencies and reduced hemoglobin (Hb) level reported 2.93(2.28, 3.78), 2.50(1.48, 4.22), 1.51(0.53, 4.29), 1.46(0.70, 3.03), and 2.14(1.38, 3.32), times more susceptible to develop RAS than healthy individuals. Conclusion The results of the meta-analysis indicated that the SMD of vitamin B12 serum and Hb levels in the case group was 52%. Our result have also showed that the odds ratio of vitamin B12, ferritin deficiencies, and decreased Hb level in case group was 2.93, 2.50, and 2.14 times more than healthy group.https://doi.org/10.1186/s12903-024-04072-5Hematological parametersRecurrent Aphthous StomatitisMeta-analysis |
| spellingShingle | Tahoora Mousavi Hossein Jalali Mahmood Moosazadeh Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis BMC Oral Health Hematological parameters Recurrent Aphthous Stomatitis Meta-analysis |
| title | Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis |
| title_full | Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis |
| title_fullStr | Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis |
| title_full_unstemmed | Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis |
| title_short | Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis |
| title_sort | hematological parameters in patients with recurrent aphthous stomatitis a systematic review and meta analysis |
| topic | Hematological parameters Recurrent Aphthous Stomatitis Meta-analysis |
| url | https://doi.org/10.1186/s12903-024-04072-5 |
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