Mast cell degranulation in periodontal disease from HIV-infected individuals
Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingiv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Campinas
2019-09-01
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| Series: | Brazilian Journal of Oral Sciences |
| Subjects: | |
| Online Access: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8656600 |
| _version_ | 1819350122581983232 |
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| author | Giovanna Ribeiro Souto Alessandro Oliveira de Jesus Takeshi Kato Segundo Paôlla Freitas Perdigão Fernando de Oliveira Costa Ricardo Alves de Mesquita |
| author_facet | Giovanna Ribeiro Souto Alessandro Oliveira de Jesus Takeshi Kato Segundo Paôlla Freitas Perdigão Fernando de Oliveira Costa Ricardo Alves de Mesquita |
| author_sort | Giovanna Ribeiro Souto |
| collection | DOAJ |
| description | Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment. |
| first_indexed | 2024-12-24T19:11:24Z |
| format | Article |
| id | doaj.art-6e5db8297b23460ca6ec0ffbca70874f |
| institution | Directory Open Access Journal |
| issn | 1677-3225 |
| language | English |
| last_indexed | 2024-12-24T19:11:24Z |
| publishDate | 2019-09-01 |
| publisher | Universidade Estadual de Campinas |
| record_format | Article |
| series | Brazilian Journal of Oral Sciences |
| spelling | doaj.art-6e5db8297b23460ca6ec0ffbca70874f2022-12-21T16:43:00ZengUniversidade Estadual de CampinasBrazilian Journal of Oral Sciences1677-32252019-09-011810.20396/bjos.v18i0.8656600Mast cell degranulation in periodontal disease from HIV-infected individualsGiovanna Ribeiro Souto0Alessandro Oliveira de Jesus1Takeshi Kato Segundo2Paôlla Freitas Perdigão3Fernando de Oliveira Costa4Ricardo Alves de Mesquita5Pontifical Catholic University of Minas GeraisFederal University of Minas GeraisFederal University of Minas GeraisD’OR Institute for Research and EducationFederal University of Minas GeraisFederal University of Minas GeraisAim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8656600Mast cellsInfectionInflammationHumansMouth mucosa. |
| spellingShingle | Giovanna Ribeiro Souto Alessandro Oliveira de Jesus Takeshi Kato Segundo Paôlla Freitas Perdigão Fernando de Oliveira Costa Ricardo Alves de Mesquita Mast cell degranulation in periodontal disease from HIV-infected individuals Brazilian Journal of Oral Sciences Mast cells Infection Inflammation Humans Mouth mucosa. |
| title | Mast cell degranulation in periodontal disease from HIV-infected individuals |
| title_full | Mast cell degranulation in periodontal disease from HIV-infected individuals |
| title_fullStr | Mast cell degranulation in periodontal disease from HIV-infected individuals |
| title_full_unstemmed | Mast cell degranulation in periodontal disease from HIV-infected individuals |
| title_short | Mast cell degranulation in periodontal disease from HIV-infected individuals |
| title_sort | mast cell degranulation in periodontal disease from hiv infected individuals |
| topic | Mast cells Infection Inflammation Humans Mouth mucosa. |
| url | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8656600 |
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