Aspirin for the Primary Prophylaxis of Colorectal Cancer
Context Increasing epidemic of colorectal cancer worldwide and the expenses of the current screening and treatment of this potentially fatal condition have raised the interest of in finding a primary prophylactic measure. Aspirin has been administrated for more than 40 years to achieve this. Evi...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2013-12-01
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| Series: | Iranian Journal of Colorectal Research |
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| Online Access: | https://colorectalresearch.sums.ac.ir/article_45458_225b0ded1a6747b0809ab9a606768aad.pdf |
| _version_ | 1828957578817699840 |
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| author | Kamran B Lankarani |
| author_facet | Kamran B Lankarani |
| author_sort | Kamran B Lankarani |
| collection | DOAJ |
| description | Context Increasing epidemic of colorectal cancer worldwide and the expenses of the current screening and treatment of this potentially fatal condition have raised the interest of in finding a primary prophylactic measure. Aspirin has been administrated for more than 40 years to achieve this. Evidence Acquisitions In this manuscript, we reviewed the best available evidence on the prophylatic use of aspirin for colorectal cancer prevention. Results The analysis and large cohort studies revealed that although using ASA would probably decrease the risk of colon cancer, this would not occur before 5-8 years after treatment. ASA usage would increase the risk of major gastrointestinal bleeding. Conclusions Aspirin has been proposed as a chemopreventive agent in colorectal cancer (CRC) for many years, but there are still debates on the proper candidates, treatment time and cost benefit analysis of this potentially harmful drug. This brief review would try to answer these questions using the currently available evidence. |
| first_indexed | 2024-12-14T08:31:31Z |
| format | Article |
| id | doaj.art-6e61bd91510648cf993d77eb8fb53259 |
| institution | Directory Open Access Journal |
| issn | 2783-2430 |
| language | English |
| last_indexed | 2024-12-14T08:31:31Z |
| publishDate | 2013-12-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Colorectal Research |
| spelling | doaj.art-6e61bd91510648cf993d77eb8fb532592022-12-21T23:09:30ZengShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24302013-12-01137810.17795/acr-1626445458Aspirin for the Primary Prophylaxis of Colorectal CancerKamran B Lankarani0Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, IR IranContext Increasing epidemic of colorectal cancer worldwide and the expenses of the current screening and treatment of this potentially fatal condition have raised the interest of in finding a primary prophylactic measure. Aspirin has been administrated for more than 40 years to achieve this. Evidence Acquisitions In this manuscript, we reviewed the best available evidence on the prophylatic use of aspirin for colorectal cancer prevention. Results The analysis and large cohort studies revealed that although using ASA would probably decrease the risk of colon cancer, this would not occur before 5-8 years after treatment. ASA usage would increase the risk of major gastrointestinal bleeding. Conclusions Aspirin has been proposed as a chemopreventive agent in colorectal cancer (CRC) for many years, but there are still debates on the proper candidates, treatment time and cost benefit analysis of this potentially harmful drug. This brief review would try to answer these questions using the currently available evidence.https://colorectalresearch.sums.ac.ir/article_45458_225b0ded1a6747b0809ab9a606768aad.pdfaspirincolorectal cancerprimary prevention |
| spellingShingle | Kamran B Lankarani Aspirin for the Primary Prophylaxis of Colorectal Cancer Iranian Journal of Colorectal Research aspirin colorectal cancer primary prevention |
| title | Aspirin for the Primary Prophylaxis of Colorectal Cancer |
| title_full | Aspirin for the Primary Prophylaxis of Colorectal Cancer |
| title_fullStr | Aspirin for the Primary Prophylaxis of Colorectal Cancer |
| title_full_unstemmed | Aspirin for the Primary Prophylaxis of Colorectal Cancer |
| title_short | Aspirin for the Primary Prophylaxis of Colorectal Cancer |
| title_sort | aspirin for the primary prophylaxis of colorectal cancer |
| topic | aspirin colorectal cancer primary prevention |
| url | https://colorectalresearch.sums.ac.ir/article_45458_225b0ded1a6747b0809ab9a606768aad.pdf |
| work_keys_str_mv | AT kamranblankarani aspirinfortheprimaryprophylaxisofcolorectalcancer |