A study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facility
Introduction: Breakthrough infections in fully vaccinated persons pose a major challenge to the ongoing vaccine campaign against SARS-CoV-2 globally. Objectives: To investigate the occurrence of breakthrough infections and the association of Covid symptoms with the vaccination status of health care...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Community Medicine |
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| Online Access: | http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=3;spage=369;epage=374;aulast=Malhotra |
| _version_ | 1811220540121153536 |
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| author | Vishal Malhotra Simmi Oberoi Ravinder Khaira Rajinder S Balgir Balpreet Kaur Sakshi Kaura |
| author_facet | Vishal Malhotra Simmi Oberoi Ravinder Khaira Rajinder S Balgir Balpreet Kaur Sakshi Kaura |
| author_sort | Vishal Malhotra |
| collection | DOAJ |
| description | Introduction: Breakthrough infections in fully vaccinated persons pose a major challenge to the ongoing vaccine campaign against SARS-CoV-2 globally. Objectives: To investigate the occurrence of breakthrough infections and the association of Covid symptoms with the vaccination status of health care workers (HCWs). Material and Methods: Done in Government Medical College, Patiala among Covid-positive HCWs who have received one or both doses of Covid vaccine, using pretested semi-structured validated Proforma and telephonic interview from April 1, 2021 to June 15, 2021. Results: Among 3388 HCWs, 115 vaccinated HCWs (1st or 2nd dose) became Covid positive. Among vaccinated Covid positive HCWs, 54 received the first dose and 61 both doses. Breakthrough infections (≥14 days post 2nd dose) occurred in 4.6% (47 of 1021) HCWs. The vaccine is significantly protective as shown by an odds ratio of 0.27; thus, vaccinated HCWs are 73% less likely to get Covid infection as compared to non-vaccinated HCWs. There was no statistically significant difference between symptom profiles of cases whether they took one or both doses of vaccine, except headache. Only tiredness and headache were reported significantly higher in the unvaccinated group in comparison to vaccinated HCWs. Conclusion; Research is needed on tracking the immune response and viral genomic sequence of samples of vaccinated Covid-positive HCWs to have constant vigilance on remerging new strains of the SARS-CoV-2. |
| first_indexed | 2024-04-12T07:44:37Z |
| format | Article |
| id | doaj.art-6e62e6ecdf22476498134ddeef8d7a36 |
| institution | Directory Open Access Journal |
| issn | 0970-0218 1998-3581 |
| language | English |
| last_indexed | 2024-04-12T07:44:37Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Community Medicine |
| spelling | doaj.art-6e62e6ecdf22476498134ddeef8d7a362022-12-22T03:41:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Community Medicine0970-02181998-35812022-01-0147336937410.4103/ijcm.ijcm_1105_21A study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facilityVishal MalhotraSimmi OberoiRavinder KhairaRajinder S BalgirBalpreet KaurSakshi KauraIntroduction: Breakthrough infections in fully vaccinated persons pose a major challenge to the ongoing vaccine campaign against SARS-CoV-2 globally. Objectives: To investigate the occurrence of breakthrough infections and the association of Covid symptoms with the vaccination status of health care workers (HCWs). Material and Methods: Done in Government Medical College, Patiala among Covid-positive HCWs who have received one or both doses of Covid vaccine, using pretested semi-structured validated Proforma and telephonic interview from April 1, 2021 to June 15, 2021. Results: Among 3388 HCWs, 115 vaccinated HCWs (1st or 2nd dose) became Covid positive. Among vaccinated Covid positive HCWs, 54 received the first dose and 61 both doses. Breakthrough infections (≥14 days post 2nd dose) occurred in 4.6% (47 of 1021) HCWs. The vaccine is significantly protective as shown by an odds ratio of 0.27; thus, vaccinated HCWs are 73% less likely to get Covid infection as compared to non-vaccinated HCWs. There was no statistically significant difference between symptom profiles of cases whether they took one or both doses of vaccine, except headache. Only tiredness and headache were reported significantly higher in the unvaccinated group in comparison to vaccinated HCWs. Conclusion; Research is needed on tracking the immune response and viral genomic sequence of samples of vaccinated Covid-positive HCWs to have constant vigilance on remerging new strains of the SARS-CoV-2.http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=3;spage=369;epage=374;aulast=Malhotracovidhcwsunvaccinatedvaccinated |
| spellingShingle | Vishal Malhotra Simmi Oberoi Ravinder Khaira Rajinder S Balgir Balpreet Kaur Sakshi Kaura A study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facility Indian Journal of Community Medicine covid hcws unvaccinated vaccinated |
| title | A study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facility |
| title_full | A study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facility |
| title_fullStr | A study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facility |
| title_full_unstemmed | A study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facility |
| title_short | A study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facility |
| title_sort | study to assess symptom profile and break through infections among health care workers post covid vaccination at tertiary care health facility |
| topic | covid hcws unvaccinated vaccinated |
| url | http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2022;volume=47;issue=3;spage=369;epage=374;aulast=Malhotra |
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